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Volume 11 Issue 2
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Comment |
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The changing landscape of the clinical value of the PM/Scl autoantibody system
Michael Mahler, Marvin J Fritzler Arthritis Research & Therapy 2009, 11:106 (26 March 2009)
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Complex genetic association of 6q23 with autoimmune rheumatic conditions
James R Maxwell, Isobel R Gowers, Anthony G Wilson Arthritis Research & Therapy 2009, 11:107 (27 April 2009)
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Rheumatoid cachexia: a complication of rheumatoid arthritis moves into the 21st century
Ronenn Roubenoff Arthritis Research & Therapy 2009, 11:108 (27 April 2009)
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Do synovial biopsies help to support evidence for involvement of innate immunity in the immunopathology of Behçet's disease?
Jan AM van Laar, Jasper H Kappen, Paul LA van Daele, P Martin van Hagen Arthritis Research & Therapy 2009, 11:109 (30 April 2009)
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Colony variability under the spotlight in animal models of arthritis
John H Robinson Arthritis Research & Therapy 2009, 11:110 (30 April 2009)
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Review |
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The inextricable link between atherosclerosis and prototypical inflammatory diseases rheumatoid arthritis and systemic lupus erythematosus
Louise E Full, Cristina Ruisanchez, Claudia Monaco Arthritis Research & Therapy 2009, 11:217 (3 April 2009)
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Insights into endocrine-immunological disturbances in autoimmunity and their impact on treatment
Maurizio Cutolo, Rainer H Straub Arthritis Research & Therapy 2009, 11:218 (6 April 2009)
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Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function
Sarah R Walmsley, Edwin R Chilvers, Moira KB Whyte Arthritis Research & Therapy 2009, 11:219 (21 April 2009)
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Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis
Christian Beyer, Georg Schett, Steffen Gay, Oliver Distler, Jörg HW Distler Arthritis Research & Therapy 2009, 11:220 (21 April 2009)
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Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis
Rik JU Lories, Frank P Luyten, Kurt de Vlam Arthritis Research & Therapy 2009, 11:221 (27 April 2009)
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Report |
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Correction: Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis
Padmalatha S Reddy, Holly M Legault, Joseph P Sypek, Mark J Collins, Elizabeth Goad, Samuel J Goldman, Wei Liu, Stuart Murray, Andrew J Dorner, Margot O'Toole Arthritis Research & Therapy 2009, 11:407 (27 April 2009)
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Correction: Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies
Carlotta Nannini, Colin P West, Patricia J Erwin, Eric L Matteson Arthritis Research & Therapy 2009, 11:408 (30 April 2009)
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Research |
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High frequency of corticosteroid and immunosuppressive therapy in patients with systemic sclerosis despite limited evidence for efficacy
Nicolas Hunzelmann, Pia Moinzadeh, Ekkehard Genth, Thomas Krieg, Walter Lehmacher, Inga Melchers, Michael Meurer, Ulf Müller-Ladner, Thorsten M Olski, Christiane Pfeiffer, Gabriela Riemekasten, Eckhard Schulze-Lohoff, Cord Sunderkoetter, Manfred Weber, the German Network for Systemic Scleroderma Centers Arthritis Research & Therapy 2009, 11:R30 (4 March 2009)
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Editor’s summary
Corticosteroids and immunosuppressive agents with potentially harmful side effects are frequently prescribed for systemic sclerosis despite limited evidence for their effectiveness, indicating the need to develop and communicate adequate treatment recommendations.
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Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: a prospective cohort study
Yuanyuan Wang, Julie Simpson, Anita E Wluka, Andrew J Teichtahl, Dallas R English, Graham G Giles, Stephen Graves, Flavia M Cicuttini Arthritis Research & Therapy 2009, 11:R31 (5 March 2009)
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Editor’s summary
Waist-to-hip ratio, body mass index and waist circumference were associated with an increased risk of knee and hip joint replacement due to severe osteoarthritis, in a study of 32,023 healthy volunteers.
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Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results
Peter C Kreuz, Sebastian Müller, Christian Ossendorf, Christian Kaps, Christoph Erggelet Arthritis Research & Therapy 2009, 11:R33 (5 March 2009)
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The effects of infliximab therapy on the serum proteome of rheumatoid arthritis patients
Ravi C Dwivedi, Navjot Dhindsa, Oleg V Krokhin, John Cortens, John A Wilkins, Hani S El-Gabalawy Arthritis Research & Therapy 2009, 11:R32 (6 March 2009)
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Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages
Thomas V Stabler, Samuel S Byers, Robert D Zura, Virginia Kraus Arthritis Research & Therapy 2009, 11:R34 (6 March 2009)
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Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study
Janny C de Grauw, Chris HA van de Lest, Paul René van Weeren Arthritis Research & Therapy 2009, 11:R35 (9 March 2009)
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Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis
Jon T Giles, Moyses Szklo, Wendy Post, Michelle Petri, Roger S Blumenthal, Gordon Lam, Allan C Gelber, Robert Detrano, William W Scott, Richard A Kronmal, Joan M Bathon Arthritis Research & Therapy 2009, 11:R36 (10 March 2009)
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Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study
Ann-Charlotte Elkan, Niclas Håkansson, Johan Frostegård, Tommy Cederholm, Ingiäld Hafström Arthritis Research & Therapy 2009, 11:R37 (10 March 2009)
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Candidate autoantigens identified by mass spectrometry in early rheumatoid arthritis are chaperones and citrullinated glycolytic enzymes
Vincent Goëb, Marlène Thomas-L'Otellier, Romain Daveau, Roland Charlionet, Patrice Fardellone, Xavier Le Loët, François Tron, Danièle Gilbert, Olivier Vittecoq Arthritis Research & Therapy 2009, 11:R38 (10 March 2009)
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Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis
Yueh-Sheng Chen, Weixing Yan, Carolyn L Geczy, Matthew A Brown, Ranjeny Thomas Arthritis Research & Therapy 2009, 11:R39 (11 March 2009)
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Microparticle-induced release of B-lymphocyte regulators by rheumatoid synoviocytes
Laurent Messer, Ghada Alsaleh, Jean-Marie Freyssinet, Fatiha Zobairi, Isabelle Leray, Jacques-Eric Gottenberg, Jean Sibilia, Florence Toti-Orfanoudakis, Dominique Wachsmann Arthritis Research & Therapy 2009, 11:R40 (16 March 2009)
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Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13
Christelle Boileau, Johanne Martel-Pelletier, Judith Caron, Philippe Msika, Georges B Guillou, Caroline Baudouin, Jean-Pierre Pelletier Arthritis Research & Therapy 2009, 11:R41 (16 March 2009)
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Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-κB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility
Rebeca Dieguez-Gonzalez, Manuel Calaza, Eva Perez-Pampin, Alejandro Balsa, Francisco J Blanco, Juan D Cañete, Rafael Caliz, Luis Carreño, Arturo R de la Serna, Benjamin Fernandez-Gutierrez, Ana Ortiz, Gabriel Herrero-Beaumont, Jose L Pablos, Javier Narvaez, Federico Navarro, Jose L Marenco, Juan J Gomez-Reino, Antonio Gonzalez Arthritis Research & Therapy 2009, 11:R42 (17 March 2009)
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Oral phosphatidylcholine pretreatment alleviates the signs of experimental rheumatoid arthritis
Gabor Erős, Saleh Ibrahim, Nikolai Siebert, Mihály Boros, Brigitte Vollmar Arthritis Research & Therapy 2009, 11:R43 (18 March 2009)
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Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis
Nadir Chabane, Nadia Zayed, Mohamed Benderdour, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Nicolas Duval, Hassan Fahmi Arthritis Research & Therapy 2009, 11:R44 (18 March 2009)
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Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study
Vitor Teixeira, Celine Pierlot, Paola Migliorini, Alejandro Balsa, René Westhovens, Pilar Barrera, Helena Alves, Carlos Vaz, Manuela Fernandes, Dora Pascual-Salcedo, Stefano Bombardieri, Jan Dequeker, Timothy R Radstake, Piet Van Riel, Leo van de Putte, Antonio Lopes-Vaz, Thomas Bardin, Bernard Prum, François Cornélis, Elisabeth Petit-Teixeira, the European Consortium on Rheumatoid Arthritis Families Arthritis Research & Therapy 2009, 11:R45 (20 March 2009)
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Adherence with urate-lowering therapies for the treatment of gout
Leslie R Harrold, Susan E Andrade, Becky A Briesacher, Marsha A Raebel, Hassan Fouayzi, Robert A Yood, Ira S Ockene Arthritis Research & Therapy 2009, 11:R46 (27 March 2009)
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Editor’s summary
Urate-lowering drugs are prescribed to manage chronic gout, a painful condition affecting an increasing number of people, but poor adherence to the medication is common, particularly amongst younger patients.
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Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc
Helen E Gruber, Jane A Ingram, Gretchen L Hoelscher, Natalia Zinchenko, Edward N Hanley, Yubo Sun Arthritis Research & Therapy 2009, 11:R47 (27 March 2009)
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Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway
Herng-Sheng Lee, Chung-Shinn Lee, Chi-Jung Yang, Sui-Long Su, Donald M Salter Arthritis Research & Therapy 2009, 11:R48 (29 March 2009)
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Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models
Jun Soo Bang, Da Hee Oh, Hyun Mi Choi, Bong-Jun Sur, Sung-Jig Lim, Jung Yeon Kim, Hyung-In Yang, Myung Chul Yoo, Dae-Hyun Hahm, Kyoung Soo Kim Arthritis Research & Therapy 2009, 11:R49 (30 March 2009)
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Increased risk of peripheral arterial disease in polymyalgia rheumatica: a population-based cohort study
Kenneth J Warrington, Elena P Jarpa, Cynthia S Crowson, Leslie T Cooper, Gene G Hunder, Eric L Matteson, Sherine E Gabriel Arthritis Research & Therapy 2009, 11:R50 (31 March 2009)
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Inflammation predicts accelerated brachial arterial wall changes in patients with recent-onset rheumatoid arthritis
Suad Hannawi, Thomas H Marwick, Ranjeny Thomas Arthritis Research & Therapy 2009, 11:R51 (6 April 2009)
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Persistence with anti-tumour necrosis factor therapies in patients with psoriatic arthritis: observational study from the British Society of Rheumatology Biologics Register
Amr A Saad, Darren M Ashcroft, Kath D Watson, Kimme L Hyrich, Peter R Noyce, Deborah PM Symmons, the British Society for Rheumatology Biologics Register Arthritis Research & Therapy 2009, 11:R52 (8 April 2009)
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Vasoactive intestinal peptide inhibits TNF-α-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands
Mario Calafat, Luciana Larocca, Valeria Roca, Vanesa Hauk, Nicolás Pregi, Alcira Nesse, Claudia Pérez Leirós Arthritis Research & Therapy 2009, 11:R53 (8 April 2009)
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Treating patients with fibromyalgia in primary care settings under routine medical practice: a claim database cost and burden of illness study
Antoni Sicras-Mainar, Javier Rejas, Ruth Navarro, Milagrosa Blanca, Ángela Morcillo, Raquel Larios, Soledad Velasco, Carme Villarroya Arthritis Research & Therapy 2009, 11:R54 (14 April 2009)
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Editor’s summary
Patients with fibromyalgia syndrome used significantly more healthcare resources and took more sick leave compared with a reference population, in a retrospective study of 1,081 subjects from Spanish primary care centres.
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Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate
Jonathan B Catterall, Daniel Barr, Michael Bolognesi, Robert D Zura, Virginia B Kraus Arthritis Research & Therapy 2009, 11:R55 (16 April 2009)
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Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse
Cuong Q Nguyen, Ashok Sharma, Byung Ha Lee, Jin-Xiong She, Richard A McIndoe, Ammon B Peck Arthritis Research & Therapy 2009, 11:R56 (20 April 2009)
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Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis
Valérie Badot, Christine Galant, Adrien Nzeusseu Toukap, Ivan Theate, Anne-Lise Maudoux, Benoît J Van den Eynde, Patrick Durez, Frédéric A Houssiau, Bernard R Lauwerys Arthritis Research & Therapy 2009, 11:R57 (23 April 2009)
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RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro
Karen A Sutherland, Helena L Rogers, Denise Tosh, Michael J Rogers Arthritis Research & Therapy 2009, 11:R58 (30 April 2009)
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Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells
Hee-Kap Kang, Diane Ecklund, Michael Liu, Syamal K Datta Arthritis Research & Therapy 2009, 11:R59 (30 April 2009)
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Editor’s summary
The dietary flavonoid apigenin inhibits inflammation in murine lupus by suppressing stimulatory functions of antigen presenting cells, suggesting a therapeutic potential in lupus and other Th17-mediated inflammatory diseases.
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Correspondence |
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5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population
Holger Kirsten, Jana Burkhardt, Helene Hantmann, Nico Hunzelmann, Peter Vaith, Peter Ahnert, Inga Melchers Arthritis Research & Therapy 2009, 11:403 (26 March 2009)
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5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population – authors' response
Lorenzo Beretta, Raffaella Scorza Arthritis Research & Therapy 2009, 11:404 (26 March 2009)
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