Figure 5.

Proximal promoters and overlapping binding regions for Sp1 and Egr-1. Proximal promoters of rat type II collagen and aggrecan, but not of link protein, have overlapping binding regions for Sp1 and Egr-1. Upstream regions of (a) the rat type II collagen, (b) aggrecan and (c) link protein were analysed by TRANSFAC [26] for transcription factor binding sites. (a) and (b) Proximal to the transcriptional start site, the type II collagen and aggrecan promoters have multiple putative Sp1 (underlined) and Egr-1 binding sites (bold), some of which are found in overlapping regions.