Table 7

Overview of Asp299Gly in TLR4: interesting deviations in allele frequencies

PubMed identifier

Gene

SNP reference

Allele

MA

MAF^a

Odds ratio (P value)

Population

Articular disease

Present study

TLR4

rs4986790

A/G

G

6%/5.0%

100 trios, French

RA

17143969

TLR4

rs4986790

A/G

G

7.5%/2.6%

3.1 (0.037)

CC 101/100, Canadian

AS

16837493

TLR4

rs4986790

A/G

G

15%/14.4%

CC 193/125, Scottish

AS

16567359

TLR4

rs4986790

A/G

G

CC AS138, ReA91/140

AS

15647432

TLR4

rs4986790

A/G

G

1.68

CC 113/170, Dutch

AS

15498795

TLR4

rs4986790

A/G

G

5%

313 trios, UK

JA

15022344

TLR4

rs4986790

A/G

G

5.3%/8.6%

CC 282/314, Dutch

RA

NCBI-SNP

TLR4

rs4986790

A/G

G

?/3.30%

CEU

N/A

NCBI-SNP

TLR4

rs4986790

A/G

G

?/0

HCB

N/A

NCBI-SNP

TLR4

rs4986790

A/G

G

?/0

JPT

N/A

NCBI-SNP

TLR4

rs4986790

A/G

G

?/3.30%

YRI

N/A

^aPresented as cases/controls. NCBI, National Center for Biotechnology Information; CEU, Utah residents with ancestry from northern and western Europe; HCB, Han Chinese in Beijing; JPT, Japanese in Tokyo; YRI, Yoruba in Ibadan, Nigeria; MA, mutation allele; MAF: mutation allele frequency; CC, case control study; RA, rheumatoid arthritis; AS, ankylosing spondylitis; JA, juvenile arthritis; N/A, not applicable.

Jaen et al. Arthritis Research & Therapy 2009 11:R5   doi:10.1186/ar2589