Table 6

Transmission disequilibrium test for TLR1–TLR6 haplotypes (rs5743618–rs5743594–rs5743810)

Overall population

RF-positive patients

Anti-CCP-positive patients

Haplotype (frequency >5%)

Transmitted/untransmitted

P value

Transmitted/untransmitted

P value

Transmitted/untransmitted

P value

GCC

16/12

0.45

13/8

0.28

12/9

0.51

GCT

28/31

0.7

21/27

0.39

22/26

0.56

GTC

12/11

0.83

10/7

0.47

9/7

0.62

TCC

20/21

0.88

18/20

0.75

18/19

0.87

Linkage disequilibrium: TLR1_SNP1 (rs5743618) – TLR1_SNP2 (rs5743594), D' = 0.94; TLR1_SNP2 (rs5743594) – TLR6_SNP1 (rs5743810), D' = 0.5. RF, rheumatoid factor; anti-CCP, anti-cyclic citrullinated peptide.

Jaen et al. Arthritis Research & Therapy 2009 11:R5   doi:10.1186/ar2589