Table 5

Transmission disequilibrium test in rheumatoid arthritis families with RF, anti-CCP antibody, or joint erosions

RF

Anti-CCP antibody

Erosions

Gene

SNP reference

Transmitted/untransmitted

P value

Transmitted/untransmitted

P value

Transmitted/untransmitted

P value

TLR1

rs5743618 (+7765 S602I)

33/28

0.52

34/29

0.53

32/32

1

rs5743594 (+3663)

15/22

0.25

14/20

0.3

20/21

0.88

TLR2

rs3804099 (+15591 N199N)

39/40

0.91

41/36

0.57

47/39

0.39

rs4696480 (-1938)

46/39

0.45

41/44

0.74

42/48

0.53

TLR4

rs2737191 (-3869)

38/35

0.73

33/36

0.72

38/42

0.65

rs4986790 (+8719 D259G)

7/9

0.62

9/12

0.51

10/11

0.83

rs1554973 (+14229)

30/30

1

25/25

1

32/31

0.9

TLR6

rs5743810 (+744 S249P)

48/41

0.46

48/44

0.68

51/49

0.84

TLR9

rs187084 (+3483 P545P)

37/35

0.81

38/35

0.73

40/39

0.91

rs352140 (-851)

36/37

0.91

34/36

0.81

37/35

0.81

RF, rheumatoid factor; anti-CCP, anti-cyclic citrullinated peptide.

Jaen et al. Arthritis Research & Therapy 2009 11:R5   doi:10.1186/ar2589