Research article
BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance
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* Corresponding author: Tibor T Glant tglant@rush.edu
1 Section of Molecular Medicine, Department of Orthopedic Surgery, Rush University Medical Center, 1735 W. Harrison Street, Cohn Research Building, Chicago, IL 60612, USA
2 Department of Immunology and Biotechnology, University of Pecs, Ifjusag u. 13, Pecs, Hungary
3 Biomedical Informatics Center, Northwestern University, 750 N. Lake Shore Drive, Chicago, IL 60611, USA
4 Department of Ophthalmology, Portland, Oregon Health Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, USA
5 Department of Internal Medicine (Section of Rheumatology), Rush University Medical Center, 1730 W. Harrison Street, Cohn Research Building, Chicago, IL 60612, USA
6 Department of Immunology/Microbiology, Rush University Medical Center, 1730 W. Harrison Street, Cohn Research Building, Chicago, IL 60612, USA
7 Department of Biochemistry, Rush University Medical Center, 1730 W. Harrison Street, Cohn Research Building, Chicago, IL 60612, USA
Arthritis Research & Therapy 2009, 11:R21 doi:10.1186/ar2613
See related editorial by Robinson, http://arthritis-research.com/content/11/2/110
Published: 16 February 2009Additional files
Additional data file 1:
Word file listing 77 genes (including 14 genes with yet unknown functions) expressed differently at significant levels in spleen cells of naive and proteoglycan-immunized (non-arthritic) mice of BALB/cJ and BALB/cByJ colonies (as shown in Fig 2 as hierarchical clusterization). Four-group cross-comparison were used: naive BALB/cJ vs. immunized BALB/cJ, naive BALB/cByJ vs. immunized BALB/cByJ, naive BALB/cJ vs. naïve BALB/cByJ and immunized BALB/cJ vs. immunized BALB/cByJ). This file contains probe set identification numbers (Affymetrix), gene symbols, names and their chromosome localization, Ensembl numbers, p values, and brief description of gene function (if known). Genes with unknown functions are highlighted in blue, and genes having immuno-regulatory function in yellow. The corresponding references of these immuno-regulatory genes are [30-65]. Original data (.cel) files are submitted to Gene Expression Omnibus (Accession Number [GEO:GSE13730]; NCBI tracking system number 15549466).
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