Table 2

Semiquantitative analysis scoring for TRAIL, TRAIL receptors, TUNEL, cleaved caspase-3, survivin and xIAP

Normal

Active RA

Inactive RA

OA

SpA

TRAIL

1.0 (0 to 3)

3.0 (1 to 4) * † ‡

2.0 (1 to 3)

2.0 (1 to 3)

2.0 (1 to 4) *

TRAIL R1

0 (0 to 2)

3.0 (0 to 4) * † ‡

1.0 (0 to 1)

2.0 (1 to 2) * †

2.0 (0 to 3) * †

TRAIL R2

0 (0 to 3)

2.0 (0 to 4) *

1.0 (0 to 3)

2.0 (0 to 3)

3.0 (1 to 3) *

TRAIL R3

2.0 (0 to 3)

4.0 (1 to 4)

2.0 (0 to 4)

3.0 (1 to 4)

4.0 (3 to 4)

TRAIL R4

1.0 (0 to 2)

3.0 (1 to 4) * ‡

3.0 (1 to 4) *

2.0 (1 to 3)

3.0 (2 to 4) *

TUNEL

0 (0 to 2)

0 (0) †

2.5 (0 to 3)

1.0 (0 to 2)

1.5 (0 to 3)

Caspase-3

0 (0 to 1)

3.0 (1 to 3) * † ‡

1.0 (0 to 1)

1.0 (0 to 1)

2.0 (0 to 2) * †

Survivin

2.0 (1 to 2)

3.0 (2 to 3) * † ‡

2.0 (1 to 2)

2.0 (1 to 2)

2.5 (0 to 3)

xIAP

0.0 (0 to 1)

2.5 (0 to 3)*

1.0 (0 to 1)

2.0 (0 to 3)

0.5 (0.0 to 2.5)

Results are presented as median scores (range).

* p < 0.05 compared with normal synovial tissue

† p < 0.05 compared with inactive rheumatoid arthritis (RA) synovial tissue.

‡ p < 0.05 compared with osteoarthritis (OA) synovial tissue.

SpA = spondyloarthropathies; TRAIL = tumour necrosis factor related apoptosis inducing ligand; TUNEL = terminal deoxynucleotidyl transferase biotin-dUTP nick end labelling; xIAP = x-linked inhibitor of apoptosis protein.

Dharmapatni et al. Arthritis Research & Therapy 2009 11:R13   doi:10.1186/ar2603