Table 5

Anti-collagen type II antibody responses in C6, C9, C10 and C11 congenic mice

Antibody isotype

B10.RIII^a

C6

C9

C10

C11

IgG1

2046^b ± 276^c

1567 ± 265

1354 ± 193

2520 ± 388*

2868 ± 576*

IgG2c

2337 ± 262

1754 ± 212

2031 ± 420

2859 ± 477

4096 ± 692**

IgG3

1873 ± 141

1364 ± 273

2144 ± 473

2483 ± 370

3021 ± 409**

IgTot

2705 ± 300

2038 ± 291

2439 ± 661

4130 ± 551**

3696 ± 543**

^aB10.RIII = littermate controls (n = 64) for mice with the different congenic fragments. The congenic intervals are outlined in Figure 5a. C6 (n = 14), C9 (n = 9), C10 (n = 15), C11 (n = 17).

^bArbitrary antibody concentration in serum. Blood was collected day 21 after immunisation. Anti-collagen type II antibodies in non-immunized mice are not detectable.

^cMean ± standard error of the mean

Statistics was calculated with Mann-Whitney U test, * p < 0.05, **p < 0.01

Lindvall et al. Arthritis Research & Therapy 2009 11:R10   doi:10.1186/ar2597