Figure 1.

Network-based analysis of downregulated genes in the functional category of immune response. (a) Network 1 and (b) Network 2 constructed by downregulated genes. (c) Network graphical representation. Genes or gene products are represented as individual nodes whose shapes represent the functional class of gene products. The biological relationship between the two nodes is represented as an edge (line). All edges are supported by at least one reference from the literature stored in the Ingenuity Pathways Knowledge Base (IPKB). Genes in colored nodes were found over-represented in the functional category of immune response. Genes in uncolored nodes were not found over-represented but were depicted by the computationally generated networks on the basis of evidence stored in the IPKB indicating a strong biologic relevance to that network.