Figure 4.

Hypoxia-inducible factor (HIF)-2α-mediated induction of cartilage matrix synthesis by human articular chondrocytes (HACs) may be possible through the inhibition of specific HIF-2α targeting prolyl hydroxylase domain (PHD) enzymes.

Murphy et al. Arthritis Research & Therapy 2009 11:213   doi:10.1186/ar2574
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