Email updates

Keep up to date with the latest news and content from Arthritis Research & Therapy and BioMed Central.

Review

Transcription profiling of rheumatic diseases

Lisa GM van Baarsen1, Carina L Bos1, Tineke CTM van der Pouw Kraan2 and Cornelis L Verweij13*

Author Affiliations

1 Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands

2 Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands

3 Department of Rheumatology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands

For all author emails, please log on.

Arthritis Research & Therapy 2009, 11:207  doi:10.1186/ar2557

Published: 30 January 2009

Abstract

Rheumatic diseases are a diverse group of disorders. Most of these diseases are heterogeneous in nature and show varying responsiveness to treatment. Because our understanding of the molecular complexity of rheumatic diseases is incomplete and criteria for categorization are limited, we mainly refer to them in terms of group averages. The advent of DNA microarray technology has provided a powerful tool to gain insight into the molecular complexity of these diseases; this technology facilitates open-ended survey to identify comprehensively the genes and biological pathways that are associated with clinically defined conditions. During the past decade, encouraging results have been generated in the molecular description of complex rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome and systemic sclerosis. Here, we describe developments in genomics research during the past decade that have contributed to our knowledge of pathogenesis, and to the identification of biomarkers for diagnosis, patient stratification and prognostication.