Radiographic progression with methotrexate is also quite variable across protocol populations, best predicted by damage at baseline. Estimated yearly progression (baseline Total Sharp/Sharp van der Heijde score divided by mean disease duration) helps to illustrate differences in protocol populations and explains differences in change scores over the course of 12 and 24 months. ERA, ASPIRE, and PREMIER represent early disease populations. ASPIRE, Active Controlled Study of Patients Receiving Infliximab for Treatment of Rheumatoid Arthritis of Early Onset; ERA, Early Rheumatoid Arthritis; MTX, methotrexate; TEMPO, Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes; TSS, Total Sharp/Sharp van der Heijde score.
Strand and Sokolove Arthritis Research & Therapy 2009 11:205 doi:10.1186/ar2555