Figure 1.

Schematic representation of T-cell receptor signal transduction. CD4-associated Lck is reciprocally regulated by CD45 and Csk/PTPN22 and in turn phosphorylates CD3 chain immunoreceptor tyrosine-based activating motifs (ITAMs) and ZAP-70. ZAP-70 phosphorylates additional downstream effectors, including the adaptors Slp-76 and Lat. Yellow bands represent CD3 chain ITAM domains. Phosphotyrosines are not depicted on all CD3 chain ITAMs. MAPK, mitogen-activated protein kinase; PLCγ1, phospholipase C γ1; TCR, T-cell antigen receptor.

Zikherman and Weiss Arthritis Research & Therapy 2009 11:202   doi:10.1186/ar2528
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