Figure 1.

Map of chromosome 1 crossover points in C57BL/6.NOD-Aec1Aec2R(n) recombinant inbred (RI) mice. Thirty-nine RI lines are aligned to show the points of their individual crossovers in the Aec2 region of chromosome 1, as determined by D1mit microsatellite markers. Crossover frequencies are higher at approximately 49.7, 74.3, and 79.0 cM but are not considered hotspots for chromosomal 1 crossovers (NS: Not significant, * = p < 0.05, ** = p < 0.01, and *** = p < 0.001).