Table 1 |
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|
Histopathology evaluation of kidneys from NZB/W F1 hybrid female mice at 42 weeks of age |
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|
Group |
Animal |
Interstitial inflammation |
Glomerular nephritis |
Tubular dilation |
|
|
|
|
|
|
|
|
|
Therapy |
Cellularity |
Membrane thickness |
|||
|
|
|
|
|||
|
None |
1 |
+2 |
-2 |
+2 |
+3 |
|
None |
2 |
+3 |
-1 |
+3 |
+3 |
|
None |
3 |
+2 |
-1 |
+3 |
+2 |
|
None |
4 |
+3 |
-3 |
+3 |
+4 |
|
None |
5 |
+3 |
-3 |
+3 |
+4 |
|
None |
Mean |
+2.6 |
-2 |
+2.8 |
+3.2 |
|
Sirolimus* |
1 |
(+1) |
0 |
+1 |
+1 |
|
Sirolimus |
2 |
(+1) |
0 |
+1 |
0 |
|
Sirolimus |
3 |
(+2) |
0 |
0 |
0 |
|
Sirolimus |
4 |
0 |
0 |
0 |
0 |
|
Sirolimus |
5 |
(+1) |
0 |
0 |
0 |
|
Sirolimus |
Mean |
+1 |
0 |
+0.4 |
0 |
|
p value, untreated versus treated |
0.004 |
0.002 |
0.00006 |
0.0001 |
|
|
|
|||||
|
0 = normal, 1 = slight, 2 = mild, 3 = moderate, 4 = marked, 5 = severe. * denotes focal not diffuse. |
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|
Reddy et al. Arthritis Research & Therapy 2008 10:R127 doi:10.1186/ar2541 |
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