Research article
Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis
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* Corresponding author: Margot O'Toole motoole@wyeth.com
- † Equal contributors
1 Biological Technologies, Wyeth Research, Cambridge, 35 CambridgePark Drive, Massachusetts 02140, USA
2 Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
3 Polysaccharides Quality, Wyeth Pharmaceutical, 1 Burtt Rd, Andover, MA 01810, USA
4 Stryker Biotech, 35 South St, Hopkinton, MA 01748, USA
5 ajDorner Consulting, 20 Baskin Road, Lexington, MA 02421, USA
Arthritis Research & Therapy 2008, 10:R127 doi:10.1186/ar2541
Published: 3 November 2008Additional files
Additional file 1:
A pdf file containing data from our laboratory confirming the published results of others on sirolimus-dependent decreases in anti-dsDNA titres.
Format: PDF Size: 177KB Download file
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Additional file 2:
A pdf file containing information about an unsupervised cluster showing relationships between mouse groups.
Format: PDF Size: 38KB Download file
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Additional file 3:
An excel file containing the FDR p values and fold change metrics for genes associated with lupus nephritis and the effect of sirolimus treatment.
Format: XLS Size: 174KB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional file 4:
An excel file containing a table that gives the information from Figure 11.
Format: XLS Size: 43KB Download file
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Additional file 5:
An excel files containing a list of 570 proteins in the mTOR interactome. All proteins known to interact with members of the rapalog-mTOR l pathway, upstream and downstream were used to create this mTOR pathway interactome.
Format: XLS Size: 99KB Download file
This file can be viewed with: Microsoft Excel Viewer