Interferon-induced versus chemokine transcripts as lupus biomarkers
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* Corresponding author: Mary K Crow crowm@hss.edu
Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
Arthritis Research & Therapy 2008, 10:126 doi:10.1186/ar2559
See related research article by Fu et al., http://arthritis-research.com/content/10/5/R112
Published: 18 December 2008Abstract
Compelling support for a central role for interferon-alpha in lupus pathogenesis has led to a new focus on the role of innate immune system activation in the generation of pathogenic mediators. These insights have been extended in translational studies of patients with well-characterized disease activity and clinical manifestations in order to identify informative molecular biomarkers. Chemokines are among the interferon-inducible genes, and new data support an association between the expression of chemokines and both lupus disease activity and organ damage. Longitudinal studies that relate molecular biomarkers to disease activity will be needed to validate these promising data and establish a sensitive measure of change for interventional studies and patient care.