Table 2

Genotype and allele frequencies of C/T transition SNP (rs143383) of the GDF5 gene in different CDH categories when stratified by severity

Group

Number of subjects (%)

Genotype (frequency)

Allele (frequency)

Hardy-Weinberg equilibrium

TT

TC

CC

T

C

P value

CDH

Instability

21 (6%)

14 (0.667)

6 (0.286)

1 (0.047)

34 (0.810)

8 (0.190)

0.74

subluxation

53 (16%)

33 (0.622)

18 (0.340)

2 (0.038)

84(0.792)

22(0.208)

0.81

Dislocation

264 (78%)

167 (0.633)

87 (0.329)

10 (0.038)

421 (0.797)

107 (0.203)

0.75

CDH = congenital dysplasia of the hip; GDF5 = growth differentiate factor 5; SNP = single nucleotide polymorphism.

Dai et al. Arthritis Research & Therapy 2008 10:R126   doi:10.1186/ar2540