Table 1

Genotype and allele frequencies of C/T transition SNP (rs143383) of the GDF5 gene in the Han Chinese population.

Group

Number of subject

Genotype (frequency)

Allele (frequency)

Hardy-Weinberg equilibrium

TT

TC

CC

T

C

P value

CDH

All

338

214 (0.633)

111 (0.328)

13 (0.039)

539 (0.797)

137 (0.203)

0.77

Female

291

185 (0.636)

95 (0.326)

11 (0.038)

465 (0.799)

117 (0.201)

0.78

Male

47

29 (0.617)

16 (0.340)

2 (0.043)

74 (0.787)

20 (0.213)

0.91

Control

All

622

342 (0.550)

234 (0.376)

46 (0.074)

918 (0.738)

326 (0.262)

0.50

Female

316

169 (0.535)

124 (0.392)

23 (0.073)

462 (0.731)

170 (0.269)

0.97

Male

306

173 (0.565)

110 (0.360)

23 (0.075)

456 (0.745)

156 (0.255)

0.35

CDH = congenital dysplasia of the hip; GDF5 = growth differentiate factor 5; SNP = single nucleotide polymorphism.

Dai et al. Arthritis Research & Therapy 2008 10:R126   doi:10.1186/ar2540