Oral administration of STA-5326 reduces the severity of experimental autoimmune uveoretinitis (EAU) by clinical and histopathological analysis. (a) Clinical score of EAU in STA-5326-treated or vehicle-treated mice. Immunized mice were treated with 5 mg/kg or 20 mg/kg STA-5326 or vehicle from day 0 to day 14 after immunization. EAU findings were evaluated on day 14 and day 18 after immunization. (b) Histopathological images of eyes from STA-5326-treated or vehicle-treated mice. Eyes enucleated on day 18 after immunization from STA-5326-treated or vehicle-treated mice were examined. Magnification ×400. (c) Histopathological score of EAU in STA-5326-treated or vehicle-treated mice. Each point on the graph represents the clinical or pathological score of one mouse. Each bar on the graph represents the average clinical or histopathological score for each group. Statistical analysis was performed by Mann-Whitney U test.
Keino et al. Arthritis Research & Therapy 2008 10:R122 doi:10.1186/ar2530