Table 2

Association of STAT4 single nucleotide polymorphisms rs10168266, rs11889341, and rs7574865 with systemic lupus erythematosus

SLE patients (n = 308)

Healthy controls (n = 306)

P value

Odds ratio

95% CI


Number

Percentage

Number

Percentage


rs10168266

Genotype frequency

C/C

118

38.3

166

54.2

C/T

147

47.7

122

39.9

7.5 × 10-5a

1.91

1.39–2.63a

T/T

43

14.0

18

5.9

Allele frequency

T

233

37.8

158

25.8

6.3 × 10-6

1.75

1.37–2.23

rs11889341

Genotype frequency

C/C

99

32.1

153

50.0

C/T

161

52.3

126

41.2

6.9 × 10-6a

2.11

1.52–2.92a

T/T

48

15.6

27

8.8

Allele frequency

T

257

41.7

180

29.4

6.6 × 10-6

1.72

1.36–2.17

rs7574865

Genotype frequency

G/G

80

26.0

133

43.5

G/T

171

55.5

141

46.1

5.3 × 10-6a

2.19

1.56–3.07a

T/T

57

18.5

32

10.5

Allele frequency

T

285

46.3

205

33.5

4.9 × 10-6

1.71

1.36–2.15

rs10168266/rs11889341/rs7574865

Haplotype frequency

CCG

52.7

65.0

1.0 × 10-5b

TTT

36.8

24.3

1.5 × 10-6b

CCT

4.9

5.1

NSb

CTT

4.6

4.1

NSb


aP values, odds ratios, and 95% confidence intervals (CIs) were calculated under the dominant model for the minor allele. bP values were calculated by permutation test using Haploview version 4.0 software. Ten million permutations were performed. NS, not significant; SLE, systemic lupus erythematosus; STAT, signal transducers and activators of transcription.

Kawasaki et al. Arthritis Research & Therapy 2008 10:R113   doi:10.1186/ar2516

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