Table 2 

Association of STAT4 single nucleotide polymorphisms rs10168266, rs11889341, and rs7574865 with systemic lupus erythematosus 

SLE patients (n = 308) 
Healthy controls (n = 306) 
P value 
Odds ratio 
95% CI 



Number 
Percentage 
Number 
Percentage 



rs10168266 

Genotype frequency 

C/C 
118 
38.3 
166 
54.2 

C/T 
147 
47.7 
122 
39.9 
7.5 × 10^{5a} 
1.91 
1.39–2.63^{a} 
T/T 
43 
14.0 
18 
5.9 

Allele frequency 

T 
233 
37.8 
158 
25.8 
6.3 × 10^{6} 
1.75 
1.37–2.23 
rs11889341 

Genotype frequency 

C/C 
99 
32.1 
153 
50.0 

C/T 
161 
52.3 
126 
41.2 
6.9 × 10^{6a} 
2.11 
1.52–2.92^{a} 
T/T 
48 
15.6 
27 
8.8 

Allele frequency 

T 
257 
41.7 
180 
29.4 
6.6 × 10^{6} 
1.72 
1.36–2.17 
rs7574865 

Genotype frequency 

G/G 
80 
26.0 
133 
43.5 

G/T 
171 
55.5 
141 
46.1 
5.3 × 10^{6a} 
2.19 
1.56–3.07^{a} 
T/T 
57 
18.5 
32 
10.5 

Allele frequency 

T 
285 
46.3 
205 
33.5 
4.9 × 10^{6} 
1.71 
1.36–2.15 
rs10168266/rs11889341/rs7574865 

Haplotype frequency 

CCG 
52.7 
65.0 
1.0 × 10^{5b} 

TTT 
36.8 
24.3 
1.5 × 10^{6b} 

CCT 
4.9 
5.1 
NS^{b} 

CTT 
4.6 
4.1 
NS^{b} 



^{a}P values, odds ratios, and 95% confidence intervals (CIs) were calculated under the dominant model for the minor allele. ^{b}P values were calculated by permutation test using Haploview version 4.0 software. Ten million permutations were performed. NS, not significant; SLE, systemic lupus erythematosus; STAT, signal transducers and activators of transcription. 

Kawasaki et al. Arthritis Research & Therapy 2008 10:R113 doi:10.1186/ar2516 