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Review

Immune regulation of bone loss by Th17 cells

Iannis E Adamopoulos* and Edward P Bowman

Author Affiliations

Department of Immunology, Schering Plough Biopharma, 901 California Avenue, Palo Alto, CA 94304, USA

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Arthritis Research & Therapy 2008, 10:225  doi:10.1186/ar2502

Published: 17 October 2008

Abstract

A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.