Arthritis Research & Therapy
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ReviewImmune regulation of bone loss by Th17 cellsIannis E Adamopoulos  and Edward P Bowman  Department of Immunology, Schering Plough Biopharma, 901 California Avenue, Palo Alto, CA 94304, USA  author email corresponding author email
Arthritis Research & Therapy 2008,
10:225doi:10.1186/ar2502
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| Published: |
17 October 2008 |
Abstract
A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation. | 
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