Figure 1.

Fracture risk given genetic marker findings. Presented is the post-test probability of fracture given the pre-test risk and findings at five most strongly fracture-associated SNPs in deCODE osteoporosis genome-wide association study [52]. P(F+/MARKERS+) indicates the probability of fracture in carriers of all five SNP risk alleles. P(F-/MARKERS-) indicates the probability of no fracture in individuals negative for all five SNP risk alleles. P(F-/MARKERS+) indicates the probability of fracture in individuals negative for all five SNP risk alleles. P(F+/MARKERS-) indicates the probability of fracture in carriers of all five SNP risk alleles. SNP, single nucleotide polymorphism.