High-density lipoprotein: does it have a dark side?
Rheumatology Division, University of Pennsylvania, 5 Maloney, Suite 509, 36th & Spruce Street Philadelphia, PA l9104-4283, USA
Arthritis Research & Therapy 2008, 10:121 doi:10.1186/ar2527
See related review article by Hahn et al., http://arthritis-research.com/content/10/4/213Published: 31 October 2008
There are proven pleiotropic anti-atherogenic actions of high-density lipoprotein (HDL). However, in systemic inflammation, HDL can have pro-inflammatory properties that may contribute to accelerated atherosclerosis, likely mediated by a change in the structure of HDL to pro-inflammatory HDL (PiHDL). Validation of the technically challenging assay for PiHDL, and confirmation of an association of PiHDL in multiple populations with known risk for atherosclerosis will eventually provide a useful biomarker. Identification of PiHDL in patients with rheumatic disease may help identify patients at risk of accelerated atherosclerosis, and focus our therapeutic interventions.