Serum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine

doi:10.1186/ar2524

Arthritis Research & Therapy

Volume 10
Issue 5

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Editorial

Serum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine

Angelo L Gaffo¹ and Kenneth G Saag²

¹Birmingham VA Medical Center, 700 19th Street South, Birmingham, AL 35233, USA

²Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, FOT 820, 1530 3^rdAvenue South, Birmingham, AL 35294, USA

author email corresponding author email

Arthritis Research & Therapy 2008, 10:120doi:10.1186/ar2524


Published:	17 October 2008

See related research by Hak and Choi, http://arthritis-research.com/content/10/5/R116

Abstract

The relationship between serum urate, menopause, and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy, Hak and Choi present a cross-sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the Third National Health and Nutritional Examination Survey. Menopause increased serum urate and hormone replacement therapy significantly decreased serum urate, although the overall level of change was small. The implications of these urate changes on gout and cardiovascular disease outcomes require further study.