An important step towards completing the rheumatoid arthritis cycle

doi:10.1186/ar2504

Arthritis Research & Therapy

Volume 10
Issue 5

Viewing options:

Abstract
Full text
PDF (145KB)

Associated material:

Related literature:

Articles citing this article
on BioMed Central
on Google Scholar
on ISI Web of Science
on PubMed Central
Other articles by authors
on Google Scholar

van Venrooij WJ
Pruijn GJ

on PubMed

van Venrooij WJ
Pruijn GJ
Related articles/pages
on Google

on Google Scholar

on PubMed

Tools:

Post to:

Editorial

An important step towards completing the rheumatoid arthritis cycle

Walther J van Venrooij and Ger JM Pruijn

Department of Biomolecular Chemistry, Radboud University Nijmegen, NL-6500 HB Nijmegen, The Netherlands

author email corresponding author email

Arthritis Research & Therapy 2008, 10:117doi:10.1186/ar2504


Published:	19 September 2008

See related research by Robinson et al., http://arthritis-research.com/content/10/4/R94

Abstract

In the previous issue of Arthritis Research & Therapy data are presented showing that circulating immune complexes containing citrullinated fibrin(ogen) are present in anti-citrullinated protein antibody-positive rheumatoid arthritis patients, and that such immune complexes co-localize with complement factor C3 in the rheumatoid synovium. These results corroborate the idea that citrullination is intimately involved in the pathophysiology of rheumatoid arthritis and complete our model (the rheumatoid arthritis cycle) for the development and chronic nature of this disease.