Arthritis Research & Therapy | Volume 10 Issue 5

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	Volume 10 Issue 5
	Comment
	Editorial Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect? Maxime Dougados Arthritis Research & Therapy 2008, 10:116 (19 September 2008) Abstract \| Full text \| PDF \| PubMed
	Editorial An important step towards completing the rheumatoid arthritis cycle Walther J van Venrooij, Ger JM Pruijn Arthritis Research & Therapy 2008, 10:117 (19 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Editorial Introducing Arthritis Research & Therapy's 10th anniversary issue, 'The Scientific Basis of Rheumatology: A Decade of Progress' Iain Hrynaszkiewicz, Peter E Lipsky, Ravinder N Maini Arthritis Research & Therapy 2008, 10:119 (10 October 2008) Full text \| PDF \| PubMed \| Cited on BioMed Central
	Editorial Serum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine Angelo L Gaffo, Kenneth G Saag Arthritis Research & Therapy 2008, 10:120 (17 October 2008) Abstract \| Full text \| PDF \| PubMed
	Editorial High-density lipoprotein: does it have a dark side? Joan M Von Feldt Arthritis Research & Therapy 2008, 10:121 (31 October 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Are biologics more effective than classical disease-modifying antirheumatic drugs? Michael T Nurmohamed, Ben AC Dijkmans Arthritis Research & Therapy 2008, 10:118 (19 September 2008) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Genetic studies in osteoporosis – the end of the beginning Emma L Duncan, Matthew A Brown Arthritis Research & Therapy 2008, 10:214 (12 September 2008) Abstract \| Full text \| PDF \| PubMed
	Review Virally associated arthritis 2008: clinical, epidemiologic, and pathophysiologic considerations Dimitrios Vassilopoulos, Leonard H Calabrese Arthritis Research & Therapy 2008, 10:215 (18 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis Stefan K Drexler, Philip L Kong, Jeremy Wales, Brian M Foxwell Arthritis Research & Therapy 2008, 10:216 (10 October 2008) Abstract \| Full text \| PDF \| PubMed
	Review Stem cell transplantation for rheumatic autoimmune diseases Thomas Hügle, Jacob M van Laar Arthritis Research & Therapy 2008, 10:217 (10 October 2008) Abstract \| Full text \| PDF \| PubMed
	Review Developments in the scientific understanding of lupus Stacy P Ardoin, David S Pisetsky Arthritis Research & Therapy 2008, 10:218 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Epigenetic modifications in rheumatoid arthritis Simon Strietholt, Britta Maurer, Marvin A Peters, Thomas Pap, Steffen Gay Arthritis Research & Therapy 2008, 10:219 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Developments in the scientific and clinical understanding of inflammatory myopathies Ingrid E Lundberg, Cecilia Grundtman Arthritis Research & Therapy 2008, 10:220 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Developments in the scientific and clinical understanding of gout Alexander So Arthritis Research & Therapy 2008, 10:221 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review What magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis – the first 50 years Dennis McGonagle, Ai Tan Arthritis Research & Therapy 2008, 10:222 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Mesenchymal stem cells in arthritic diseases Faye H Chen, Rocky S Tuan Arthritis Research & Therapy 2008, 10:223 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Vascular involvement in rheumatic diseases: 'vascular rheumatology' Zoltán Szekanecz, Alisa E Koch Arthritis Research & Therapy 2008, 10:224 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Immune regulation of bone loss by Th17 cells Iannis E Adamopoulos, Edward P Bowman Arthritis Research & Therapy 2008, 10:225 (17 October 2008) Abstract \| Full text \| PDF \| PubMed
	Review Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on? Aleksander M Grabiec, Paul P Tak, Kris A Reedquist Arthritis Research & Therapy 2008, 10:226 (17 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Report
	Correction Correction: Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus Thomas Dörner, Joerg Kaufmann, William A Wegener, Nick Teoh, David M Goldenberg, Gerd R Burmester Arthritis Research & Therapy 2008, 10:406 (9 September 2008) Full text \| PDF
	Correction Correction: Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis C Thomas G Appleton, David D McErlain, Vasek Pitelka, Neil Schwartz, Suzanne M Bernier, James L Henry, David W Holdsworth, Frank Beier Arthritis Research & Therapy 2008, 10:407 (22 September 2008) Full text \| PDF
	Research
	Research article A polymorphism in the human serotonin 5-HT_2Areceptor gene may protect against systemic sclerosis by reducing platelet aggregation Lorenzo Beretta, Marta Cossu, Maurizio Marchini, Francesca Cappiello, Andrea Artoni, Giovanna Motta, Raffaella Scorza Arthritis Research & Therapy 2008, 10:R103 (1 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article The relationship between inflammation and new bone formation in patients with ankylosing spondylitis Xenofon Baraliakos, Joachim Listing, Martin Rudwaleit, Joachim Sieper, Juergen Braun Arthritis Research & Therapy 2008, 10:R104 (1 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ankylosing spondylitis patients treated with anti-TNF agents show new bone formation mostly in areas of spinal inflammation, suggesting more effective suppression of inflammation may lead to stronger inhibition of structural damage.
	Research article Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab Sanna Rosengren, Nathan Wei, Kenneth C Kalunian, Nathan J Zvaifler, Arthur Kavanaugh, David L Boyle Arthritis Research & Therapy 2008, 10:R105 (1 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Prognostic factors of 10-year radiographic outcome in early rheumatoid arthritis: a prospective study Natacha Courvoisier, Maxime Dougados, Alain Cantagrel, Philippe Goupille, Olivier Meyer, Jean Sibilia, Jean Daures, Bernard Combe Arthritis Research & Therapy 2008, 10:R106 (4 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article 4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase France Vaillancourt, Hassan Fahmi, Qin Shi, Patrick Lavigne, Pierre Ranger, Julio C Fernandes, Mohamed Benderdour Arthritis Research & Therapy 2008, 10:R107 (9 September 2008) Abstract \| Full text \| PDF \| PubMed \| F1000
	Research article Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity Joan Wither, Yong-chun Cai, Sooyeol Lim, Tamara McKenzie, Nicole Roslin, Jaime O Claudio, Glinda S Cooper, Thomas J Hudson, Andrew D Paterson, Celia MT Greenwood, Dafna Gladman, Janet Pope, Christian A Pineau, C Douglas Smith, John G Hanly, Christine Peschken, Gilles Boire, CaNIOS Investigators, Paul R Fortin Arthritis Research & Therapy 2008, 10:R108 (10 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary First-degree relatives of patients with lupus may be genetically predisposed to the development of autoimmunity due to altered immunoregulation resulting from reduced proportions of regulatory natural killer T cells.
	Research article Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus Richard Furie, William Stohl, Ellen M Ginzler, Michael Becker, Nilamadhab Mishra, Winn Chatham, Joan T Merrill, Arthur Weinstein, W Joseph McCune, John Zhong, Wendy Cai, William Freimuth, the Belimumab Study Group Arthritis Research & Therapy 2008, 10:R109 (11 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Belimumab, a human monoclonal antibody, was well tolerated and biologically active in 70 systemic lupus erythematosus patients, supporting the initiation of phase II trials in patients with autoimmune diseases.
	Research article Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis Bence György, László Tóthfalusi, György Nagy, Mária Pásztói, Pál Géher, Zsolt Lörinc, Anna Polgár, Bernadett Rojkovich, Ilona Ujfalussy, Gyula Poór, Péter Pócza, Zoltán Wiener, Petra Misják, Agnes Koncz, András Falus, Edit I Buzás Arthritis Research & Therapy 2008, 10:R110 (12 September 2008) Abstract \| Full text \| PDF \| PubMed
	Research article Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints Kolja Gelse, David Pfander, Simon Obier, Karl X Knaup, Michael Wiesener, Friedrich F Hennig, Bernd Swoboda Arthritis Research & Therapy 2008, 10:R111 (12 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients Qiong Fu, Xiaoqing Chen, Huijuan Cui, Yanzhi Guo, Jing Chen, Nan Shen, Chunde Bao Arthritis Research & Therapy 2008, 10:R112 (15 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region Aya Kawasaki, Ikue Ito, Koki Hikami, Jun Ohashi, Taichi Hayashi, Daisuke Goto, Isao Matsumoto, Satoshi Ito, Akito Tsutsumi, Minori Koga, Tadao Arinami, Robert R Graham, Geoffrey Hom, Yoshinari Takasaki, Hiroshi Hashimoto, Timothy W Behrens, Takayuki Sumida, Naoyuki Tsuchiya Arthritis Research & Therapy 2008, 10:R113 (19 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	Research article Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus Seetha U Monrad, Kristine Rea, Seth Thacker, Mariana J Kaplan Arthritis Research & Therapy 2008, 10:R114 (23 September 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lupus dendritic cells have diminished endocytic capacity that correlates with decreased mannose receptor expression, which may be relevant to the aberrant immune homeostasis and increased susceptibility to infections described in lupus.
	Research article Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease Melina Daans, Rik JU Lories, Frank P Luyten Arthritis Research & Therapy 2008, 10:R115 (24 September 2008) Abstract \| Full text \| PDF \| PubMed
	Research article Menopause, postmenopausal hormone use and serum uric acid levels in US women – The Third National Health and Nutrition Examination Survey A Elisabeth Hak, Hyon K Choi Arthritis Research & Therapy 2008, 10:R116 (26 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis Teresia M Osborn, Margareta Verdrengh, Thomas P Stossel, Andrej Tarkowski, Maria Bokarewa Arthritis Research & Therapy 2008, 10:R117 (27 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression Masaya Hayashi, Takeshi Muneta, Young-Jin Ju, Tomoyuki Mochizuki, Ichiro Sekiya Arthritis Research & Therapy 2008, 10:R118 (30 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Weekly intra-articular injections of bone morphogenic protein-7 inhibit the progression of osteoarthritis in rabbits, without inducing adverse effects, such as synovial fibrosis, or ectopic bone or osteophyte formation.
	Research article Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination Brian A Kidd, Peggy P Ho, Orr Sharpe, Xiaoyan Zhao, Beren H Tomooka, Jennifer L Kanter, Lawrence Steinman, William H Robinson Arthritis Research & Therapy 2008, 10:R119 (30 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000
	Research article Rationale for prostaglandin I₂in bone marrow oedema – from theory to application Marcus Jäger, Frank Tillmann, Thomas S Thornhill, Marcus Mahmoudi, Dirk Blondin, Gerd Hetzel, Christoph Zilkens, Rüdiger Krauspe Arthritis Research & Therapy 2008, 10:R120 (3 October 2008) Abstract \| Full text \| PDF \| PubMed
	Research article Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis Yoshifumi Tada, Syuichi Koarada, Fumitaka Morito, Mio Mitamura, Hisako Inoue, Rie Suematsu, Akihide Ohta, Kensuke Miyake, Kohei Nagasawa Arthritis Research & Therapy 2008, 10:R121 (11 October 2008) Abstract \| Full text \| PDF \| PubMed
	Research article Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis Hiroshi Keino, Takayo Watanabe, Yasuhiko Sato, Mamoru Niikura, Yumiko Wada, Annabelle A Okada Arthritis Research & Therapy 2008, 10:R122 (13 October 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Oral administration of the IL-12/IL-23 inhibitor, STA-5326, effectively suppresses inflammation in the experimental autoimmune uveoretinitis mouse model, suggesting it may serve as a potential therapeutic agent for human refractory uveitis.
	Research article Vitamin D deficiency in undifferentiated connective tissue disease Eva Zold, Peter Szodoray, Janos Gaal, János Kappelmayer, Laszlo Csathy, Edit Gyimesi, Margit Zeher, Gyula Szegedi, Edit Bodolay Arthritis Research & Therapy 2008, 10:R123 (18 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 \| Editor’s summary A study of 161 patients with undifferentiated connective tissue disease suggests that vitamin D deficiency may be associated with the disease progressing into well-defined connective tissue diseases such as rheumatoid arthritis.
	Research article Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies Carlotta Nannini, Colin P West, Patricia J Erwin, Eric L Matteson Arthritis Research & Therapy 2008, 10:R124 (20 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 \| Editor’s summary A systematic review and meta-analysis finds that cyclophosphamide treatment in patients with systemic sclerosis-related interstitial lung disease does not result in clinically significant improvement in pulmonary function.
	Research article Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment Heiner Appel, Louise Janssen, Joachim Listing, René Heydrich, Martin Rudwaleit, Joachim Sieper Arthritis Research & Therapy 2008, 10:R125 (22 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study Jin Dai, Dongquan Shi, Pengsheng Zhu, Jianghui Qin, Haijian Ni, Yong Xu, Chen Yao, Lunqing Zhu, Hongtao Zhu, Baocheng Zhao, Jia Wei, Baorui Liu, Shiro Ikegawa, Qing Jiang, Yitao Ding Arthritis Research & Therapy 2008, 10:R126 (24 October 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In Han Chinese patients a single nucleotide polymorphism located in the promoter region of the GDF5 gene was significantly associated with congenital dysplasia of the hip, a common congenital skeletal abnormality.

	Volume 10 Issue 5
	Comment
	Editorial Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect? Maxime Dougados Arthritis Research & Therapy 2008, 10:116 (19 September 2008) Abstract \| Full text \| PDF \| PubMed
	Editorial An important step towards completing the rheumatoid arthritis cycle Walther J van Venrooij, Ger JM Pruijn Arthritis Research & Therapy 2008, 10:117 (19 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Editorial Introducing Arthritis Research & Therapy's 10th anniversary issue, 'The Scientific Basis of Rheumatology: A Decade of Progress' Iain Hrynaszkiewicz, Peter E Lipsky, Ravinder N Maini Arthritis Research & Therapy 2008, 10:119 (10 October 2008) Full text \| PDF \| PubMed \| Cited on BioMed Central
	Editorial Serum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine Angelo L Gaffo, Kenneth G Saag Arthritis Research & Therapy 2008, 10:120 (17 October 2008) Abstract \| Full text \| PDF \| PubMed
	Editorial High-density lipoprotein: does it have a dark side? Joan M Von Feldt Arthritis Research & Therapy 2008, 10:121 (31 October 2008) Abstract \| Full text \| PDF \| PubMed
	Commentary Are biologics more effective than classical disease-modifying antirheumatic drugs? Michael T Nurmohamed, Ben AC Dijkmans Arthritis Research & Therapy 2008, 10:118 (19 September 2008) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Genetic studies in osteoporosis – the end of the beginning Emma L Duncan, Matthew A Brown Arthritis Research & Therapy 2008, 10:214 (12 September 2008) Abstract \| Full text \| PDF \| PubMed
	Review Virally associated arthritis 2008: clinical, epidemiologic, and pathophysiologic considerations Dimitrios Vassilopoulos, Leonard H Calabrese Arthritis Research & Therapy 2008, 10:215 (18 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis Stefan K Drexler, Philip L Kong, Jeremy Wales, Brian M Foxwell Arthritis Research & Therapy 2008, 10:216 (10 October 2008) Abstract \| Full text \| PDF \| PubMed
	Review Stem cell transplantation for rheumatic autoimmune diseases Thomas Hügle, Jacob M van Laar Arthritis Research & Therapy 2008, 10:217 (10 October 2008) Abstract \| Full text \| PDF \| PubMed
	Review Developments in the scientific understanding of lupus Stacy P Ardoin, David S Pisetsky Arthritis Research & Therapy 2008, 10:218 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Epigenetic modifications in rheumatoid arthritis Simon Strietholt, Britta Maurer, Marvin A Peters, Thomas Pap, Steffen Gay Arthritis Research & Therapy 2008, 10:219 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Developments in the scientific and clinical understanding of inflammatory myopathies Ingrid E Lundberg, Cecilia Grundtman Arthritis Research & Therapy 2008, 10:220 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Developments in the scientific and clinical understanding of gout Alexander So Arthritis Research & Therapy 2008, 10:221 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review What magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis – the first 50 years Dennis McGonagle, Ai Tan Arthritis Research & Therapy 2008, 10:222 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Mesenchymal stem cells in arthritic diseases Faye H Chen, Rocky S Tuan Arthritis Research & Therapy 2008, 10:223 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Vascular involvement in rheumatic diseases: 'vascular rheumatology' Zoltán Szekanecz, Alisa E Koch Arthritis Research & Therapy 2008, 10:224 (10 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Immune regulation of bone loss by Th17 cells Iannis E Adamopoulos, Edward P Bowman Arthritis Research & Therapy 2008, 10:225 (17 October 2008) Abstract \| Full text \| PDF \| PubMed
	Review Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on? Aleksander M Grabiec, Paul P Tak, Kris A Reedquist Arthritis Research & Therapy 2008, 10:226 (17 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Report
	Correction Correction: Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus Thomas Dörner, Joerg Kaufmann, William A Wegener, Nick Teoh, David M Goldenberg, Gerd R Burmester Arthritis Research & Therapy 2008, 10:406 (9 September 2008) Full text \| PDF
	Correction Correction: Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis C Thomas G Appleton, David D McErlain, Vasek Pitelka, Neil Schwartz, Suzanne M Bernier, James L Henry, David W Holdsworth, Frank Beier Arthritis Research & Therapy 2008, 10:407 (22 September 2008) Full text \| PDF
	Research
	Research article A polymorphism in the human serotonin 5-HT_2Areceptor gene may protect against systemic sclerosis by reducing platelet aggregation Lorenzo Beretta, Marta Cossu, Maurizio Marchini, Francesca Cappiello, Andrea Artoni, Giovanna Motta, Raffaella Scorza Arthritis Research & Therapy 2008, 10:R103 (1 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article The relationship between inflammation and new bone formation in patients with ankylosing spondylitis Xenofon Baraliakos, Joachim Listing, Martin Rudwaleit, Joachim Sieper, Juergen Braun Arthritis Research & Therapy 2008, 10:R104 (1 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ankylosing spondylitis patients treated with anti-TNF agents show new bone formation mostly in areas of spinal inflammation, suggesting more effective suppression of inflammation may lead to stronger inhibition of structural damage.
	Research article Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab Sanna Rosengren, Nathan Wei, Kenneth C Kalunian, Nathan J Zvaifler, Arthur Kavanaugh, David L Boyle Arthritis Research & Therapy 2008, 10:R105 (1 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Prognostic factors of 10-year radiographic outcome in early rheumatoid arthritis: a prospective study Natacha Courvoisier, Maxime Dougados, Alain Cantagrel, Philippe Goupille, Olivier Meyer, Jean Sibilia, Jean Daures, Bernard Combe Arthritis Research & Therapy 2008, 10:R106 (4 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article 4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase France Vaillancourt, Hassan Fahmi, Qin Shi, Patrick Lavigne, Pierre Ranger, Julio C Fernandes, Mohamed Benderdour Arthritis Research & Therapy 2008, 10:R107 (9 September 2008) Abstract \| Full text \| PDF \| PubMed \| F1000
	Research article Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity Joan Wither, Yong-chun Cai, Sooyeol Lim, Tamara McKenzie, Nicole Roslin, Jaime O Claudio, Glinda S Cooper, Thomas J Hudson, Andrew D Paterson, Celia MT Greenwood, Dafna Gladman, Janet Pope, Christian A Pineau, C Douglas Smith, John G Hanly, Christine Peschken, Gilles Boire, CaNIOS Investigators, Paul R Fortin Arthritis Research & Therapy 2008, 10:R108 (10 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary First-degree relatives of patients with lupus may be genetically predisposed to the development of autoimmunity due to altered immunoregulation resulting from reduced proportions of regulatory natural killer T cells.
	Research article Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus Richard Furie, William Stohl, Ellen M Ginzler, Michael Becker, Nilamadhab Mishra, Winn Chatham, Joan T Merrill, Arthur Weinstein, W Joseph McCune, John Zhong, Wendy Cai, William Freimuth, the Belimumab Study Group Arthritis Research & Therapy 2008, 10:R109 (11 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Belimumab, a human monoclonal antibody, was well tolerated and biologically active in 70 systemic lupus erythematosus patients, supporting the initiation of phase II trials in patients with autoimmune diseases.
	Research article Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis Bence György, László Tóthfalusi, György Nagy, Mária Pásztói, Pál Géher, Zsolt Lörinc, Anna Polgár, Bernadett Rojkovich, Ilona Ujfalussy, Gyula Poór, Péter Pócza, Zoltán Wiener, Petra Misják, Agnes Koncz, András Falus, Edit I Buzás Arthritis Research & Therapy 2008, 10:R110 (12 September 2008) Abstract \| Full text \| PDF \| PubMed
	Research article Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints Kolja Gelse, David Pfander, Simon Obier, Karl X Knaup, Michael Wiesener, Friedrich F Hennig, Bernd Swoboda Arthritis Research & Therapy 2008, 10:R111 (12 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients Qiong Fu, Xiaoqing Chen, Huijuan Cui, Yanzhi Guo, Jing Chen, Nan Shen, Chunde Bao Arthritis Research & Therapy 2008, 10:R112 (15 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region Aya Kawasaki, Ikue Ito, Koki Hikami, Jun Ohashi, Taichi Hayashi, Daisuke Goto, Isao Matsumoto, Satoshi Ito, Akito Tsutsumi, Minori Koga, Tadao Arinami, Robert R Graham, Geoffrey Hom, Yoshinari Takasaki, Hiroshi Hashimoto, Timothy W Behrens, Takayuki Sumida, Naoyuki Tsuchiya Arthritis Research & Therapy 2008, 10:R113 (19 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment
	Research article Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus Seetha U Monrad, Kristine Rea, Seth Thacker, Mariana J Kaplan Arthritis Research & Therapy 2008, 10:R114 (23 September 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lupus dendritic cells have diminished endocytic capacity that correlates with decreased mannose receptor expression, which may be relevant to the aberrant immune homeostasis and increased susceptibility to infections described in lupus.
	Research article Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease Melina Daans, Rik JU Lories, Frank P Luyten Arthritis Research & Therapy 2008, 10:R115 (24 September 2008) Abstract \| Full text \| PDF \| PubMed
	Research article Menopause, postmenopausal hormone use and serum uric acid levels in US women – The Third National Health and Nutrition Examination Survey A Elisabeth Hak, Hyon K Choi Arthritis Research & Therapy 2008, 10:R116 (26 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis Teresia M Osborn, Margareta Verdrengh, Thomas P Stossel, Andrej Tarkowski, Maria Bokarewa Arthritis Research & Therapy 2008, 10:R117 (27 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression Masaya Hayashi, Takeshi Muneta, Young-Jin Ju, Tomoyuki Mochizuki, Ichiro Sekiya Arthritis Research & Therapy 2008, 10:R118 (30 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Weekly intra-articular injections of bone morphogenic protein-7 inhibit the progression of osteoarthritis in rabbits, without inducing adverse effects, such as synovial fibrosis, or ectopic bone or osteophyte formation.
	Research article Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination Brian A Kidd, Peggy P Ho, Orr Sharpe, Xiaoyan Zhao, Beren H Tomooka, Jennifer L Kanter, Lawrence Steinman, William H Robinson Arthritis Research & Therapy 2008, 10:R119 (30 September 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000
	Research article Rationale for prostaglandin I₂in bone marrow oedema – from theory to application Marcus Jäger, Frank Tillmann, Thomas S Thornhill, Marcus Mahmoudi, Dirk Blondin, Gerd Hetzel, Christoph Zilkens, Rüdiger Krauspe Arthritis Research & Therapy 2008, 10:R120 (3 October 2008) Abstract \| Full text \| PDF \| PubMed
	Research article Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis Yoshifumi Tada, Syuichi Koarada, Fumitaka Morito, Mio Mitamura, Hisako Inoue, Rie Suematsu, Akihide Ohta, Kensuke Miyake, Kohei Nagasawa Arthritis Research & Therapy 2008, 10:R121 (11 October 2008) Abstract \| Full text \| PDF \| PubMed
	Research article Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis Hiroshi Keino, Takayo Watanabe, Yasuhiko Sato, Mamoru Niikura, Yumiko Wada, Annabelle A Okada Arthritis Research & Therapy 2008, 10:R122 (13 October 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Oral administration of the IL-12/IL-23 inhibitor, STA-5326, effectively suppresses inflammation in the experimental autoimmune uveoretinitis mouse model, suggesting it may serve as a potential therapeutic agent for human refractory uveitis.
	Research article Vitamin D deficiency in undifferentiated connective tissue disease Eva Zold, Peter Szodoray, Janos Gaal, János Kappelmayer, Laszlo Csathy, Edit Gyimesi, Margit Zeher, Gyula Szegedi, Edit Bodolay Arthritis Research & Therapy 2008, 10:R123 (18 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 \| Editor’s summary A study of 161 patients with undifferentiated connective tissue disease suggests that vitamin D deficiency may be associated with the disease progressing into well-defined connective tissue diseases such as rheumatoid arthritis.
	Research article Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies Carlotta Nannini, Colin P West, Patricia J Erwin, Eric L Matteson Arthritis Research & Therapy 2008, 10:R124 (20 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 \| Editor’s summary A systematic review and meta-analysis finds that cyclophosphamide treatment in patients with systemic sclerosis-related interstitial lung disease does not result in clinically significant improvement in pulmonary function.
	Research article Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment Heiner Appel, Louise Janssen, Joachim Listing, René Heydrich, Martin Rudwaleit, Joachim Sieper Arthritis Research & Therapy 2008, 10:R125 (22 October 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study Jin Dai, Dongquan Shi, Pengsheng Zhu, Jianghui Qin, Haijian Ni, Yong Xu, Chen Yao, Lunqing Zhu, Hongtao Zhu, Baocheng Zhao, Jia Wei, Baorui Liu, Shiro Ikegawa, Qing Jiang, Yitao Ding Arthritis Research & Therapy 2008, 10:R126 (24 October 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In Han Chinese patients a single nucleotide polymorphism located in the promoter region of the GDF5 gene was significantly associated with congenital dysplasia of the hip, a common congenital skeletal abnormality.

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