Table 7

KEGG pathways/complexes significantly affected by intra-group inter-individual gene expression variance in osteoarthritis (OA) compared with rheumatoid arthritis (that is, higher variances in OA)

KEGG identification number

Pathway/complex

B (E)

χ²

P value

Affected genes

1

hsa00190

Oxidative phosphorylation^a

10 (1)

75.6

<0.01

COX5B, NDUFA6, NDUFA8, NDUFB2, NDUFB4, SDHC, NDUFB6, aNDUFC1, NDUFA13, ATP5G3

2

hsa04010

MAPK signaling pathway^a

5 (2)

3.8

0.17

DUSP5, RASGRP3, FAS, MAPK11, TAOK1

2a

hsa04010

MAPK signaling pathway^a (JNK/p38 MAPK sub-pathway)

4 (1)

6.54

0.03

DUSP5, FAS, MAPK11, TAOK1

3

hsa00790

Folate biosynthesis^a

3 (0)

22.03

<0.01

ASCC3, SETX, SMARCA5

4

hsa00500

Starch and sucrose metabolism^a

3 (1)

7.86

0.01

ASCC3, SETX, SMARCA5

^aSpecifically affected in rheumatoid arthritis. B, absolute frequency; E, expected frequency; JNK, c-jun kinase; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase.

Huber et al. Arthritis Research & Therapy 2008 10:R98   doi:10.1186/ar2485