Research article
Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane
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* Corresponding author: Raimund W Kinne Raimund.W.Kinne@med.uni-jena.de
1 Experimental Rheumatology Unit, Department of Orthopedics, University Hospital Jena, Waldkrankenhaus 'Rudolf Elle', Klosterlausnitzer Str. 81, 07607 Eisenberg, Germany
2 Institute for Clinical Chemistry, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
3 Systems Biology/Bioinformatics Group, Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Beutenbergstr. 11a, 07745 Jena, Germany
4 Genome Analysis, Leibniz Institute for Age Research – Fritz Lipmann Institute, Beutenbergstr. 11, 07745 Jena, Germany
5 Proteome Center Rostock, University of Rostock, Schillingallee 69, 18055 Rostock, Germany
Arthritis Research & Therapy 2008, 10:R98 doi:10.1186/ar2485
Published: 22 August 2008Additional files
Additional file 1:
'Supplementary Table 1A: Genes affected by intra-group, inter-individual mRNA expression variances (RA compared to NC)', 'Supplementary Table 1B: Genes affected by intra-group, inter-individual mRNA expression variances (OA compared to NC)', 'Supplementary Table 1C: Genes affected by intra-group, inter-individual mRNA expression variances (RA compared to OA)'. For KEGG analyses, relevant genes were selected according to (i) a significance level of p ≤ 0.05 (Bonferroni/Holm corrected Brown-Forsythe version of the Levene test) for variance-fold values and (ii) a cutoff value for absolute variance-fold levels of > 2.5 for higher variances in RA, OA, and NC, respectively. (A) 568 genes were selected for the comparison between RA and NC (307 with higher variances in RA, 261 with higher variances in NC), (B) 542 genes were used for the comparison OA versus NC (314 with higher variances in OA, 228 with higher variances in NC), and (C) 333 genes were selected for the comparison between RA and OA (186 with higher variances in RA, 147 with higher variances in OA). All genes are sorted according to absolute variance-fold values.
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