Figure 5.

Known interactions between genes differentially expressed in FLSs from DA and DA.F344(Cia5d). Several estrogen (β-estradiol)-regulated genes, including genes involved in increasing either the expression or activity of matrix metalloproteinase (MMP)-2, such as Cxcl10, Nras, and Vil2 were differentially expressed. Green indicates downregulated in DA.F344(Cia5d) and upregulated in DA. Red indicates upregulated in DA.F344(Cia5d) and downregulated in DA. White indicates that the gene is part of the pathway but was not differentially expressed in fibroblast-like synoviocytes (FLSs) from the two strains. Color intensity correlates with magnitude of the expression difference.