Table 1

Histological findings of knee joints in the meniscectomized rabbit osteoarthritis model
Histological findings of synoviuma
 Meniscectomy group (n = 6)
 Sham group (n = 4)
 Normal group (n = 4)


0
 1+
 2+
 3+
 4+
 0
 1+
 2+
 3+
 4+
 0
 1+
 2+
 3+
 4+
H&E staining














     Hyperplasia of synovial cell
 0
 0
 5
 1
 0
 1
 0
 3
 0
 0
 4
 0
 0
 0
 0
     Fibrosis in connective tissue
 0
 0
 1
 5
 0
 0
 0
 1
 3
 0
 4
 0
 0
 0
 0
     Inflammatory cell infiltration in connective tissue
 4
 0
 1
 1
 0
 4
 0
 0
 0
 0
 4
 0
 0
 0
 0
KM1334 immunohistochemistryb














     Positive reactions in synovial cells
 0
 6
 0
 0
 0
 1
 3
 0
 0
 0
 3c
 1
 0
 0
 0
     Positive reactions in fibroblastic cells
 0
 5
 1
 0
 0
 0
 4
 0
 0
 0
 4
 0
 0
 0
 0
     Positive reactions in cartilage
 6c
 0
 0
 0
 0
 4
 0
 0
 0
 0
 4c
 0
 0
 0
 0
Cartilage degeneration scorec (mean ± standard error)
 6.0 ± 0.8
 0.5 ± 0.5
 0.0 ± 0.0

aHistological findings criteria: 0, non remarkable; 1+, very slight; 2+, slight, 3+, moderate; 4+, marked. bKM1334; an anti-FGF8 antibody. cSafranin O/fast green staining sample examined using the modified Mankin scale.

Uchii et al. Arthritis Research & Therapy 2008 10:R90   doi:10.1186/ar2474

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