Figure 6.

Effect of FGF8 on monoiodoacetic acid-induced sulfated glycosaminoglycan release in the knee joint of rats. Monoiodoacetic acid (MIA) was injected into the right knee joint of rats (vehicle). KM1334 (the anti-FGF8 antibody (Ab)) was intraperitoneally administered before the injection of MIA. As a control, sterile saline was injected into the knee instead of MIA (saline). The synovial lavage was performed with saline 3 days after the intraarticular injection of MIA into knee joints. The content of sulfated glycosaminoglycan (S-GAG) in an aliquot was measured by the 1,9-dimethylmethylene blue method. Each column represents the mean ± standard error (n = 10). ^##P < 0.01 compared with the sham group (Aspin–Welch test), *P < 0.05 compared with the vehicle group (Aspin–Welch test).