Table 3

Immunohistochemical characterisation of extracellular matrix (ECM) formed by adipose-derived mesenchymal stem cells (AD-MSC) in 3D culture for two to five weeksa

ECM protein

Mean histological grading score

Mean of four experiments +/- standard deviation


- TGFβ

+ TGFβ


Keratin sulphateb

1.5 ± 0.58

2.5 ± 0.58

Chondroitin sulphate

2.5 ± 0.58

3.0 ± 0.00

Collagenb type I

2.4 ± 0.42

3.0 ± 0.00

Collagen type II

2.4 ± 0.42

2.6 ± 0.42

Decorinb

1.5 ± 0.58

2.3 ± 0.50


aScoring scale: 1 = very slight localization; 2 = modest localisation; 3 = abundant localisation. bTranforming growth factor beta (TGFβ) treated cells gave a significantly higher score compared with untreated cells (p < 0.05).

Tapp et al. Arthritis Research & Therapy 2008 10:R89   doi:10.1186/ar2473

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