Table 3 |
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Immunohistochemical characterisation of extracellular matrix (ECM) formed by adipose-derived mesenchymal stem cells (AD-MSC) in 3D culture for two to five weeksa |
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|
ECM protein |
Mean histological grading score Mean of four experiments +/- standard deviation |
|
|
|
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|
- TGFβ |
+ TGFβ |
|
|
|
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|
Keratin sulphateb |
1.5 ± 0.58 |
2.5 ± 0.58 |
|
Chondroitin sulphate |
2.5 ± 0.58 |
3.0 ± 0.00 |
|
Collagenb type I |
2.4 ± 0.42 |
3.0 ± 0.00 |
|
Collagen type II |
2.4 ± 0.42 |
2.6 ± 0.42 |
|
Decorinb |
1.5 ± 0.58 |
2.3 ± 0.50 |
|
|
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|
aScoring scale: 1 = very slight localization; 2 = modest localisation; 3 = abundant localisation. bTranforming growth factor beta (TGFβ) treated cells gave a significantly higher score compared with untreated cells (p < 0.05). |
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Tapp et al. Arthritis Research & Therapy 2008 10:R89 doi:10.1186/ar2473 |
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