Table 2

Histological grading of proteoglycan extracellular matrix formation by adipose-derived mesenchymal stem cells (AD-MSC) seeded into 3D matrixa

Age of donor sand rat

Number of weeks of cultured

Mean histological grading score (mean +/- standard deviation)


- TGFβ

+ TGFβb


10 weeks

3 to 5

2.0 ± 0.0 (3)

3.0 ± 0.0 (3)

6 months

3 to 6

1.0 ± 0.0 (3)

2.7 ± 0.47 (3)

20 months

3 to 4

1.3 (2)

3.3 (2)


aScoring scale: 0 = no localization; 1 = very slight localization; 2 = modest localization; 3 = abundant localisation. bTransforming growth factor beta (TGFβ) treated AD-MSC gave a significantly higher score compared with untreated cells (p < 0.05).

Tapp et al. Arthritis Research & Therapy 2008 10:R89   doi:10.1186/ar2473

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