Table 4

Summary of possible candidate genes on chromosome 11 for Cia40/Pregq2

Gene

Position, mb

Description

Reproductive or inflammatory phenotypes of mutation

Ngfr

95.430132 – 95.449049

Nerve growth factor receptor

Perinatal lethality

Phb

95.5528271 – 95.542087

Prohibitin

Lethality before weaning

Igf2bp1

95.818477 – 95.867254

Insulin-like growth factor 2

Fetal growth

Med24

96.565905 – 98.590749

Mediator complex subunit 24

Pups die prior to birth

Gsdm3

98.490658 – 98.499540

Gasdermin

Abnormal loss of skin and hair

Etv4

101.631061 – 101.646685

Ets variant gene 4 (E1A enhancer-binding protein, E1AF)

Mammary gland abnormality, male infertility

Cd79b^a

106.172655 – 106.176076

CD79B antigen

Hematopoietic, immune

Prkar1a

109.510719 – 109.530970

Protein kinase, cAMP-dependent regulatory, type I, alpha

Embryonic lethality

Abca8a^a

109.886948 – 109.957292

ATP-binding cassette, sub-family A (ABC1), member 8a

Not known

Map2k6^a

110.260436 – 110.386836

Mitogen-activated protein kinase kinase 6

Abnormal immune system

Sox9

112.643538 – 112.649074

SRY-box containing gene 9

Perinatal lethality, cartilage formation, sex reversal

^aPolymorfism between inbreed strains of NMRI and C57BL/10 according to gscan, Wellcome Trust Centre for Human Genetics [13]. Mb for the genes/markers are according to Mouse Ensemble built 36 [18].

Liljander et al. Arthritis Research & Therapy 2008 10:R88   doi:10.1186/ar2470