Table 5

Genotype frequencies of IL-4/IL-13 variants and production of autoantibodies

Gene

SNP

Genotypes

Anti-CCP status^a

RF status^a

Positive (n)

Negative (n)

OR (95% CI)

P

Positive (n)

Negative (n)

OR (95% CI)

P

IL-13

rs1800925

TT

17

8

0.6 (0.3–1.8)

0.3^b

16

7

1.0 (0.4–3.0)

1.0^b

CT

207

59

1.1 (0.7–1.5)

0.8

170

82

0.9 (0.7–1.3)

0.6

CC

458

138

1.0

387

171

1.0

rs1295686

TT

20

6

1.0 (0.4–3.0)

1.0^b

16

10

0.7 (0.3–1.8)

0.5^b

CT

192

54

1.0 (0.7–1.5)

0.8

161

72

1.0 (0.7–1.4)

1.0

CC

439

128

1.0

367

165

1.0

IL-4

rs2227284

AA

42

14

0.8 (0.4–1.7)

0.5

33

21

0.7 (0.4–14)

0.3

AC

232

74

0.8 (0.6–1.2)

0.3

202

89

1.0 (0.8–1.5)

0.8

CC

419

113

1.0

338

156

1.0

rs2243263

CC

5

3

0.5 (0.09–3.1)

0.4^b

5

3

0.8 (0.1–5.0)

0.7^b

AC

102

38

0.8 (0.5–1.2)

0.2

89

44

0.9 (0.6–1.4)

0.2

AA

568

160

1.0

465

213

1.0

rs2243267

CC

17

1

5.2 (0.8–218.9)

0.09^b

13

4

1.5 (0.4–6.2)

0.6^b

CG

167

48

1.1 (0.7–1.6)

0.9

142

64

1.0 (0.7–1.4)

1.0

GG

503

154

1.0

422

190

1.0

IL-4R

rs1805010

GG

150

43

0.8 (0.5–1.4)

0.4

122

59

0.8 (0.5–1.3)

0.3

AG

341

109

0.8 (0.5–1.2)

0.2

288

136

0.8 (0.6–1.2)

0.3

AA

196

50

1.0

165

64

1.0

rs1801275

AA

31

5

2.0 (0.7–6.6)

0.2

26

9

1.4 (0.6–3.4)

0.6

AG

241

71

1.1 (0.8–1.5)

0.7

197

92

1.0 (0.7–1.4)

1.0

GG

416

131

1.0

351

165

1.0

^aThe presence of anti-cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF) was compared for each single nucleotide polymorphism (SNP) with reference to the commonest genotype. ^bBy Fisher's exact test for association. CI, confidence interval; OR, odds ratio.

Marinou et al. Arthritis Research & Therapy 2008 10:R80   doi:10.1186/ar2454