Table 4

Genotype frequencies of the genes involved in the IL-4/IL-13 pathway and modified Larsen score

Gene

SNP

Genotypes

Patients (n)

Median LSa

P


IL-13

rs1800925

TT

26

31.0

CT

271

27.0

0.8

CC

608

28.0

rs1295686

TT

26

33.5

CT

251

25.0

0.8

CC

580

28.0

IL-4

rs2227284

AA

56

27.0

AC

316

29.0

0.6b

CC

541

29.0

rs2243263

CC

8

41.5

AC

146

26.0

0.3

AA

738

28.0

rs2243267

CC

18

23.5

CG

218

29.0

0.9

GG

672

28.0

IL-4R

rs1805010

GG

198

24.5

AG

460

30.0

0.5

AA

250

29.0

rs1801275

AA

38

28.0

AG

316

27.5

0.5

GG

558

29.0


aMaximum possible modified (Larsen score) is 160. bBy Cuzick's test for trend. SNP, single nucleotide polymorphism.

Marinou et al. Arthritis Research & Therapy 2008 10:R80   doi:10.1186/ar2454

Open Data