Table 1

Genotype frequencies and RA susceptibility

Gene

SNP

Genotypes

RA (n [%])

Controls (n [%])

OR (95% CI)

P value


IL-13

rs1800925

TT

26 (2.9)

26 (2.8)

1.0 (0.6–1.9)

0.9

CT

271 (29.9)

276 (29.6)

1.0 (0.8–1.3)

0.9

CC

608 (67.2)

631 (67.6)

1.0

rs1295686

TT

26 (3.0)

31 (3.3)

0.9 (0.5–1.6)

0.7

CT

251 (29.3)

283 (30.4)

0.9 (0.8–1.2)

0.6

CC

580 (67.7)

617 (66.3)

1.0

IL-4

rs2227284

AA

56 (6.1)

47 (4.9)

1.2 (0.8–1.9)

0.3

AC

316 (34.6)

349 (36.7)

0.9 (0.8–1.1)

0.4

CC

541 (59.3)

554 (58.3)

1.0

rs2243263

CC

8 (0.9)

6 (0.6)

1.4 (0.4–4.8)

0.6a

GC

146 (16.4)

166 (17.9)

0.9 (0.7–1.2)

0.4

GG

738 (82.7)

753 (81.4)

1.0

rs2243267

CC

18 (2.0)

17 (1.8)

1.1 (0.5–2.3)

0.8a

CG

218 (24.0)

205 (22.2)

1.1 (0.9–1.4)

0.4

GG

672 (74.0)

702 (76.0)

1.0

IL-4R

rs1805010

GG

198 (21.8)

200 (21.3)

1.2 (0.9–1.5)

0.2

AG

460 (50.7)

438 (46.6)

1.3 (1.0–1.6)

0.03

AA

250 (27.5)

301 (32.1)

1.0

rs1801275

AA

38 (4.2)

41 (4.3)

1.0 (0.6–1.6)

1.0

AG

316 (34.6)

302 (32.0)

1.1 (0.9–1.4)

0.2

GG

558 (61.2)

601 (63.7)

1.0


aFisher's exact test. CI, confidence interval; OR, odds ratio; RA, rheumatoid arthritis.

Marinou et al. Arthritis Research & Therapy 2008 10:R80   doi:10.1186/ar2454

Open Data