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Alternative splice variants selected for functional testing |
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| Splice variant |
Clone |
Length of ORFa |
Length of ECDa |
C-terminal novel amino acidsb |
|
|
|
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| 1 |
VEGFR1-541 |
018C02 |
541 |
758 |
LPPANSSFML PPTSFSSNYF HFLP* |
| 2 |
VEGFR2-712 |
015F01 |
712 |
764 |
E* |
| 3 |
VEGFR3-765 |
015G09 |
765 |
775 |
REGGPGEGQV RRPARPTIPN PGGPAPPPHP LQESTWRTPT RS* |
| 4 |
Met-877 |
020H07 |
877 |
932 |
VRNALNTVLN HQLKLN* |
| 5 |
Tie1-751 |
016G03 |
751 |
759 |
ERAGPTGPPG L* |
| 6 |
CSF1R-306 |
005A06 |
306 |
512 |
GTPSPSLCPA * |
| 7 |
c-Kit-413 |
002H01 |
413 |
520 |
SL* |
| 8 |
PDGFRβ-336 |
007C09 |
336 |
531 |
RAATCGSWER WAHYNLLSCI GAGHCR* |
| 9 |
FGFR1-320 |
022C02 |
320 |
374 |
GTHCNFSSRC PALATGTGGA CISRLGETQR QESWKNGLLP AWCHILPQL* |
| 10 |
RAGE-387 |
021C06 |
387 |
342 |
IGETSPQALQ TLGLGCRTAQ ALISCPILAL SLTATPPLPP CTHTQASPAP PAFCQESSQA SPFFPLS* |
|
Ten alternative splice variants were selected for functional testing. aLengths of the alternative splice variant open-reading frames (ORF) and lengths of the wildtype receptor extracellular domains (ECD) are indicated by the numbers of amino acids. bNovel C-terminal amino acids of each alternative splice variant are shown. *Stop codon. | |||||
Jin et al. Arthritis Research & Therapy 2008 10:R73 doi:10.1186/ar2447 |
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