Table 2

Alternative splice variants selected for functional testing


Splice variant
Clone
Length of ORFa
Length of ECDa
C-terminal novel amino acidsb

1
VEGFR1-541
018C02
541
758
LPPANSSFML PPTSFSSNYF HFLP*
2
VEGFR2-712
015F01
712
764
E*
3
VEGFR3-765
015G09
765
775
REGGPGEGQV RRPARPTIPN PGGPAPPPHP LQESTWRTPT RS*
4
Met-877
020H07
877
932
VRNALNTVLN HQLKLN*
5
Tie1-751
016G03
751
759
ERAGPTGPPG L*
6
CSF1R-306
005A06
306
512
GTPSPSLCPA *
7
c-Kit-413
002H01
413
520
SL*
8
PDGFRβ-336
007C09
336
531
RAATCGSWER WAHYNLLSCI GAGHCR*
9
FGFR1-320
022C02
320
374
GTHCNFSSRC PALATGTGGA CISRLGETQR QESWKNGLLP AWCHILPQL*
10
RAGE-387
021C06
387
342
IGETSPQALQ TLGLGCRTAQ ALISCPILAL SLTATPPLPP CTHTQASPAP PAFCQESSQA SPFFPLS*

Ten alternative splice variants were selected for functional testing. aLengths of the alternative splice variant open-reading frames (ORF) and lengths of the wildtype receptor extracellular domains (ECD) are indicated by the numbers of amino acids. bNovel C-terminal amino acids of each alternative splice variant are shown. *Stop codon.

Jin et al. Arthritis Research & Therapy 2008 10:R73   doi:10.1186/ar2447