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Framingham analysis: independent association of standardized biomarkers with BML (BML > 0) per SD of change in marker |
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| Marker |
Adjusted for age, sex, and BMI |
Multi-adjusted (adjusted for age, sex, BMI, and BMD) |
Multi-adjusted (Adjusted for OA, age, sex, BMI, and BMD) |
|
|
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| Ln-BSAP |
1.4 (0.9 to 2.1) |
1.4 (0.9 to 2.0) |
1.26 (0.75 to 2.11) |
| Ln-osteocalcin |
1.1 (0.7 to 1.7) |
1.1 (0.7 to 1.7) |
1.60 (0.99 to 2.57) |
| Ln-NTx |
1.7 (1.1 to 2.7) |
1.7 (1.1 to 2.6) |
1.65 (0.96 to 2.83) |
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Values are presented as odds ratio (95% confidence interval). BML, bone marrow; BSAP, bone-specific alkaline phosphatase; Ln, Natural Log; NTx, type I collagen N-telopeptide; SD, standard deviation. | |||
Hunter et al. Arthritis Research & Therapy 2008 10:R102 doi:10.1186/ar2494 |
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