|
BOKS analysis: independent association of standardized biomarkers with BML (BML > 0) per SD of change in marker |
|||||||
| Univariate association |
Full model (including age, sex and BMI) |
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|
|
|||||||
| Marker |
(BML = 0) |
(BML > 0) |
OR |
95% CI |
R2 |
Full model R2 |
Full model ROC area |
|
|
|||||||
| Ln-BSAP |
3.48 (0.35) |
3.57 (0.36) |
1.4 |
(0. 9, 2.0) |
2.58 |
14.56 |
0.701 |
| Ln-osteocalcin |
2.73 (0.51) |
2.80 (0.55) |
1.2 |
(0.8, 1.7) |
0.8 |
13.41 |
0.687 |
| Ln-NTx |
-3.47 (1.07) |
-3.27 (0.78) |
1.4 |
(1.0, 2.0) |
3.05 |
14.55 |
0.697 |
|
BMI, body mass index; BML, bone marrow; BOKS, Boston Osteoarthritis Knee Study; BSAP, bone-specific alkaline phosphatase; Ln, Natural Log; NTx, type I collagen N-telopeptide; SD, standard deviation. | |||||||
Hunter et al. Arthritis Research & Therapy 2008 10:R102 doi:10.1186/ar2494 |
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