Arthritis Research & Therapy

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Biochemical markers of bone turnover and their association with bone marrow lesions

David J Hunter*, Michael LaValley, Jiang Li, Doug C Bauer, Michael Nevitt, Jeroen DeGroot, Robin Poole, David Eyre, Ali Guermazi, Daniel Gale, Saara Totterman and David T Felson

Arthritis Research & Therapy 2008, 10:R102 doi:10.1186/ar2494

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Research article   Open Access

Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized

David J Hunter, Lou Gerstenfeld, Gavin Bishop, A David Davis, Zach D Mason, Tom A Einhorn, Rose A Maciewicz, Pete Newham, Martyn Foster, Sonya Jackson, Elise F Morgan Arthritis Research & Therapy 2009, 11:R11 (26 January 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

Bone marrow lesions adjacent to the subchondral plate in osteoarthritis patients awaiting a total knee replacement appear to be sclerotic, and have a lower mineral density than healthy bone.

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