Table 2

Lipid levels and carotid plaque in patients with rheumatic diseases [47-50,55-59]

Increase in risk for atherosclerosis

Total cholesterol

LDL-C

HDL-C

Triglycerides

OxLDL

Anti-oxLDL

PiHDL

Plaque/IMT on carotid ultrasound


SLE

OR 7 (general), 50 (females 35 to 44 years old)

Normal

Normal

↓ or normal

Normal

↑↑

↑ plaque all ages

Decade 3: 6%

Decade 4: 13%

Decade 5: 33%

Decade 6: 73%

Rheumatoid arthritis

3

↓ or normal

↓ or normal

↑ plaque all ages

Decade 3: 7%

Decade 4: 52%,

Decade 5: 52%

Psoriatic arthritis

1.6

↑ or normal

↓ or ↑

Not done

Not done

Not done

Not done

↑ IMT overall

Ankylosing spondylitis

1.6

↑ or normal

Not done

Not done

Not done

Not done

↑ IMT in patients with high BASMI score

Vasculitis

Not found

Normal

Normal

Normal

Normal

Not done

Not done

↑ plaque: 58%


↑, increased; ↑↑, significantly increased; ↓, decreased; BASMI, Bath Ankylosing Spondylitis Metrology Index; HDL-C, high-density lipoprotein cholesterol; IMT, intima-media thickness; LDL-C, low-density lipoprotein cholesterol; OR, odds ratio; oxLDL, oxidized low-density lipoprotein; piHDL, proinflammatory high-density lipoprotein; SLE, systemic lupus erythematosus.

Hahn et al. Arthritis Research & Therapy 2008 10:213   doi:10.1186/ar2471