Table 2 |
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|
Lipid levels and carotid plaque in patients with rheumatic diseases [47-50,55-59] |
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|
Increase in risk for atherosclerosis |
Total cholesterol |
LDL-C |
HDL-C |
Triglycerides |
OxLDL |
Anti-oxLDL |
PiHDL |
Plaque/IMT on carotid ultrasound |
|
|
|
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|
SLE |
OR 7 (general), 50 (females 35 to 44 years old) |
Normal |
Normal |
↓ or normal |
Normal |
↑ |
↑ |
↑↑ |
↑ plaque all ages |
|
Decade 3: 6% |
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|
Decade 4: 13% |
|||||||||
|
Decade 5: 33% |
|||||||||
|
Decade 6: 73% |
|||||||||
|
Rheumatoid arthritis |
3 |
↓ or normal |
↓ or normal |
↓ |
↑ |
↑ |
↑ |
↑ |
↑ plaque all ages |
|
Decade 3: 7% |
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|
Decade 4: 52%, |
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|
Decade 5: 52% |
|||||||||
|
Psoriatic arthritis |
1.6 |
↑ or normal |
↓ or ↑ |
↓ |
Not done |
Not done |
Not done |
Not done |
↑ IMT overall |
|
Ankylosing spondylitis |
1.6 |
↑ or normal |
↑ |
↓ |
Not done |
Not done |
Not done |
Not done |
↑ IMT in patients with high BASMI score |
|
Vasculitis |
Not found |
Normal |
Normal |
Normal |
Normal |
Not done |
↑ |
Not done |
↑ plaque: 58% |
|
|
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|
↑, increased; ↑↑, significantly increased; ↓, decreased; BASMI, Bath Ankylosing Spondylitis Metrology Index; HDL-C, high-density lipoprotein cholesterol; IMT, intima-media thickness; LDL-C, low-density lipoprotein cholesterol; OR, odds ratio; oxLDL, oxidized low-density lipoprotein; piHDL, proinflammatory high-density lipoprotein; SLE, systemic lupus erythematosus. |
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|
Hahn et al. Arthritis Research & Therapy 2008 10:213 doi:10.1186/ar2471 |
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