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Review

Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis

Bevra H Hahn*, Jennifer Grossman, Benjamin J Ansell, Brian J Skaggs and Maureen McMahon

Author Affiliations

Divisions of Rheumatology and Cardiology, David Geffen School of Medicine at University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA

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Arthritis Research & Therapy 2008, 10:213  doi:10.1186/ar2471


See related editorial by Von Feldt, http://arthritis-research.com/content/10/5/121

Published: 29 August 2008

Abstract

In this review, the authors discuss the formation and structure of high-density lipoproteins (HDLs) and how those particles are altered in inflammatory or stress states to lose their capacity for reverse cholesterol transport and for antioxidant activity. In addition, abnormal HDLs can become proinflammatory (piHDLs) and actually contribute to oxidative damage. The assay by which piHDLs are identified involves studying the ability of test HDLs to prevent oxidation of low-density lipoproteins. Finally, the authors discuss the potential role of piHDLs (found in some 45% of patients with systemic lupus erythematosus and 20% of patients with rheumatoid arthritis) in the accelerated atherosclerosis associated with some chronic rheumatic diseases.