Table 1

Genetics in fibromyalgia

Reference

Year of study

Number of subjects

Number of control

Objective measure

Findings

Bondy and colleagues [5]

1999

168 FMS

115

5-HT2A, T102C polymorphism

Different from control, but not significant for specific allele

Gürsoy and colleagues [6]

2001

58 FMS

58

5-HT2A, T102C polymorphism

Not significant

Gürsoy and colleagues [7]

2003

61 FMS

61

COMT haplotype

Over-representation of LL variant (low activity). Similar to migraine and TMD

Offenbaecher and colleagues [8]

1999

62 FMS

110

5-HTT

One positive for over-representative SS genotype, one negative study. Suggestion that any association might be related to comorbid psychology

Gürsoy [9]

2002

53 FMS

60 mentally healthy

5-HTT

Yunus and colleagues [4]

1999

40 multicase families

HLA

Linkage to HLA

Buskila and colleagues [10]

2004

Dopamine D₄ receptor polymorphism

Decrease in the frequency of the seven-repeat allele in exon III of the D₄ receptor gene associated with fibromyalgia. Finding associated with low novelty-seeking personality

COMT, catecholamine o-methyl transferase; FMS, fibromyalgia syndrome; 5-HT2A, serotonergic 5-hydroxytryptamine 2A receptor (T/T phenotype); 5-HTT, serotonin transporter; TMD, temporomandibular disorder.

Dadabhoy et al. Arthritis Research & Therapy 2008 10:211   doi:10.1186/ar2443