Altered fractalkine cleavage results in an organ-specific 17 kDa fractalkine fragment in salivary glands of NOD mice
1 Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Haukelandsveien 28, Bergen 5021, Norway
2 Department of Rheumatology, Haukeland University Hospital, Bergen, Jonas Liesvei 65, Bergen 5021, Norway
3 Department of Otolaryngology, Head and Neck Surgery, Haukeland University Hospital, Bergen, Jonas Liesvei 65, Bergen 5021, Norway
Arthritis Research & Therapy 2008, 10:114 doi:10.1186/ar2458
See related research by Wildenberg et al., http://arthritis-research.com/content/10/3/R69Published: 31 July 2008
Sjögren's syndrome is a rheumatic disease in which the salivary and lacrimal glands are the principal targets of a pathological autoimmune reaction. Previous studies in mice indicated that delayed organogenesis and aberrant cell physiology followed by an increase in acinar cell apoptosis precede chronic focal inflammation in the salivary glands and the manifestation of impaired exocrine gland secretion. In a recent study by Wildenberg and colleagues, the authors report aberrant proteolytic activity in the salivary glands of non-obese diabetic mice and the generation of a unique organ-specific 17 kDa fragment of the chemokine and adhesion molecule fractalkine.