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Volume 10 Issue 4
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Comment |
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Altered fractalkine cleavage results in an organ-specific 17 kDa fractalkine fragment in salivary glands of NOD mice
Nicolas Delaleu, Roland Jonsson Arthritis Research & Therapy 2008, 10:114 (31 July 2008)
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Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation: therapeutic implications
Manolis Heliotis, Eleftherios Tsiridis Arthritis Research & Therapy 2008, 10:115 (12 August 2008)
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Review |
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High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?
Ranjeny Thomas, Malcolm Turner, Andrew P Cope Arthritis Research & Therapy 2008, 10:210 (24 July 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome
Dina Dadabhoy, Leslie J Crofford, Michael Spaeth, I Jon Russell, Daniel J Clauw Arthritis Research & Therapy 2008, 10:211 (8 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis
Keith D Brown, Estefania Claudio, Ulrich Siebenlist Arthritis Research & Therapy 2008, 10:212 (21 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis
Bevra H Hahn, Jennifer Grossman, Benjamin J Ansell, Brian J Skaggs, Maureen McMahon Arthritis Research & Therapy 2008, 10:213 (29 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Report |
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Correction: Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?
Stephen Eyre, John Bowes, Catherine Potter, Jane Worthington, Anne Barton Arthritis Research & Therapy 2008, 10:405 (8 August 2008)
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Research |
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Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis
Pei Jin, Juan Zhang, Percy F Sumariwalla, Irene Ni, Brett Jorgensen, Damian Crawford, Suzanne Phillips, Marc Feldmann, H Michael Shepard, Ewa M Paleolog Arthritis Research & Therapy 2008, 10:R73 (1 July 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Alternative splice variants - proteins derived from the receptor tyrosine kinase superfamily - markedly reduced arthritis severity in an in vivo study, showing they have potential as therapeutic agents.
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Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2
Wasim S Khan, Simon R Tew, Adetola B Adesida, Timothy E Hardingham Arthritis Research & Therapy 2008, 10:R74 (3 July 2008)
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Presence and utility of IgA-class antibodies to cyclic citrullinated peptides in early rheumatoid arthritis: the Swedish TIRA project
Anna Svärd, Alf Kastbom, Åsa Reckner-Olsson, Thomas Skogh Arthritis Research & Therapy 2008, 10:R75 (4 July 2008)
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The renal metallothionein expression profile is altered in human lupus nephritis
Mikkel Faurschou, Milena Penkowa, Claus Andersen, Henrik Starklint, Søren Jacobsen Arthritis Research & Therapy 2008, 10:R76 (6 July 2008)
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Low-intensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures: a basic science study
Ryohei Takeuchi, Akihide Ryo, Noriko Komitsu, Yuko Mikuni-Takagaki, Atsuko Fukui, Yuta Takagi, Toshihiko Shiraishi, Shin Morishita, Yoshiyuki Yamazaki, Ken Kumagai, Ichiro Aoki, Tomoyuki Saito Arthritis Research & Therapy 2008, 10:R77 (11 July 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Ultrasound properties of articular cartilage in the tibio-femoral joint in knee osteoarthritis: relation to clinical assessment (International Cartilage Repair Society grade)
Hiroshi Kuroki, Yasuaki Nakagawa, Koji Mori, Masahiko Kobayashi, Ko Yasura, Yukihiro Okamoto, Takashi Suzuki, Kohei Nishitani, Takashi Nakamura Arthritis Research & Therapy 2008, 10:R78 (13 July 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues
James Melrose, Emily S Fuller, Peter J Roughley, Margaret M Smith, Briedgeen Kerr, Clare E Hughes, Bruce Caterson, Christopher B Little Arthritis Research & Therapy 2008, 10:R79 (14 July 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Lack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis
Ioanna Marinou, Simon H Till, David J Moore, Anthony G Wilson Arthritis Research & Therapy 2008, 10:R80 (14 July 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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A meta-analysis of the efficacy of fibromyalgia treatment according to level of care
Javier Garcia-Campayo, Jesus Magdalena, Rosa Magallón, Esther Fernández-García, Montserrat Salas, Eva Andrés Arthritis Research & Therapy 2008, 10:R81 (15 July 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Treating fibromyalgia in specialized care offers no clear advantages over its routine management in primary care settings, finds a meta-analysis of 33 trials assessing 120 treatment interventions on 7789 patients.
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Brain-derived neurotrophic factor and its receptor in the human and the sand rat intervertebral disc
Helen E Gruber, Jane A Ingram, Gretchen Hoelscher, Natalia Zinchenko, H James Norton, Edward N Hanley Arthritis Research & Therapy 2008, 10:R82 (17 July 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells
Sasa Janjanin, Farida Djouad, Rabie M Shanti, Dolores Baksh, Kiran Gollapudi, Drago Prgomet, Lars Rackwitz, Arjun S Joshi, Rocky S Tuan Arthritis Research & Therapy 2008, 10:R83 (28 July 2008)
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Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect
Hideyuki Koga, Masayuki Shimaya, Takeshi Muneta, Akimoto Nimura, Toshiyuki Morito, Masaya Hayashi, Shiro Suzuki, Young-Jin Ju, Tomoyuki Mochizuki, Ichiro Sekiya Arthritis Research & Therapy 2008, 10:R84 (29 July 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
A novel synovial mesenchymal stem cell transplantation method in rabbits promotes cartilage regeneration and is less invasive than current therapy, requiring neither periosteal coverage nor scaffold use.
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A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee
Krishanu Sengupta, Krishnaraju V Alluri, Andey Satish, Simanchala Mishra, Trimurtulu Golakoti, Kadainti VS Sarma, Dipak Dey, Siba P Raychaudhuri Arthritis Research & Therapy 2008, 10:R85 (30 July 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Medicine | F1000 Biology
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Editor’s summary
An enriched extract of the Indian frankincense herb, Boswellia serrata reduced pain and improved the physical function of osteoarthritis patients, in a double blind, randomized, placebo controlled trial.
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Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration
Philip Jones, Lucy Gardner, Janis Menage, Gwyn T Williams, Sally Roberts Arthritis Research & Therapy 2008, 10:R86 (1 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration
Sarah Heathfield, Christine Le Maitre, Judith Hoyland Arthritis Research & Therapy 2008, 10:R87 (5 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2 fragments
Maria Liljander, Åsa Andersson, Rikard Holmdahl, Ragnar Mattsson Arthritis Research & Therapy 2008, 10:R88 (6 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix
Hazel Tapp, Ray Deepe, Jane A Ingram, Marshall Kuremsky, Edward N Hanley, Helen E Gruber Arthritis Research & Therapy 2008, 10:R89 (11 August 2008)
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Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis
Masako Uchii, Tadafumi Tamura, Toshio Suda, Masakazu Kakuni, Akira Tanaka, Ichiro Miki Arthritis Research & Therapy 2008, 10:R90 (12 August 2008)
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Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells
Xiangyang Huang, Nan Shen, Chunde Bao, Yueying Gu, Li Wu, Shunle Chen Arthritis Research & Therapy 2008, 10:R91 (15 August 2008)
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Cia5d regulates a new fibroblast-like synoviocyte invasion-associated gene expression signature
Teresina Laragione, Max Brenner, Wentian Li, Pércio S Gulko Arthritis Research & Therapy 2008, 10:R92 (15 August 2008)
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TH-17 cells in rheumatoid arthritis
Shiva Shahrara, QiQuan Huang, Arthur M Mandelin, Richard M Pope Arthritis Research & Therapy 2008, 10:R93 (18 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis
Xiaoyan Zhao, Nwora Okeke, Orr Sharpe, Franak M Batliwalla, Annette T Lee, Peggy P Ho, Beren H Tomooka, Peter K Gregersen, William H Robinson Arthritis Research & Therapy 2008, 10:R94 (18 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Development of a health care utilisation data-based index for rheumatoid arthritis severity: a preliminary study
Gladys Ting, Sebastian Schneeweiss, Richard Scranton, Jeffrey N Katz, Michael E Weinblatt, Melissa Young, Jerry Avorn, Daniel H Solomon Arthritis Research & Therapy 2008, 10:R95 (21 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc
Helen E Gruber, Paul Bornstein, E Helene Sage, Jane A Ingram, Natalia Zinchenko, H James Norton, Edward N Hanley Arthritis Research & Therapy 2008, 10:R96 (21 August 2008)
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Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus: relationship to neuropsychiatric symptoms
Annie George-Chandy, Estelle Trysberg, Kristina Eriksson Arthritis Research & Therapy 2008, 10:R97 (22 August 2008)
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Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane
René Huber, Christian Hummert, Ulrike Gausmann, Dirk Pohlers, Dirk Koczan, Reinhard Guthke, Raimund W Kinne Arthritis Research & Therapy 2008, 10:R98 (22 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc
Devina Purmessur, Anthony J Freemont, Judith A Hoyland Arthritis Research & Therapy 2008, 10:R99 (27 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Induction of HLA-B27 heavy chain homodimer formation after activation in dendritic cells
Susana G Santos, Sarah Lynch, Elaine C Campbell, Antony N Antoniou, Simon J Powis Arthritis Research & Therapy 2008, 10:R100 (29 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
Kaleb M Pauley, Minoru Satoh, Annie L Chan, Michael R Bubb, Westley H Reeves, Edward KL Chan Arthritis Research & Therapy 2008, 10:R101 (29 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Medicine | F1000 Biology
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Editor’s summary
MicroRNA expression in rheumatoid arthritis patients' peripheral blood mononuclear cells mimics that of synovial tissue and fibroblasts, and is a potentially useful marker for disease diagnosis, progression, or treatment efficacy.
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Biochemical markers of bone turnover and their association with bone marrow lesions
David J Hunter, Michael LaValley, Jiang Li, Doug C Bauer, Michael Nevitt, Jeroen DeGroot, Robin Poole, David Eyre, Ali Guermazi, Daniel Gale, Saara Totterman, David T Felson Arthritis Research & Therapy 2008, 10:R102 (29 August 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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