Table 1

The 12 air pouch membrane mRNAs most highly upregulated by MSU crystals
Gene
 Genbank accession number
 Ref.
 Linear ratio: MSU/control
 Function
 Function(s)









Inflammationa
 MSUb
PUMA-g (GPR 109/HM74)
 NM 030701
 [29]
 64.2
 +
 -
 Macrophage activation, prostaglandin synthesis
Hdc
 AF 109137
 [46]
 33.8
 +
 ±
 Histamine synthesis
TREM-1
 NM 021406
 [15]
 31.9
 +
 +
 Expressed on activated macrophages, neutrophils
CSF3 (also known as G-CSF)
 NM 007782
 [47]
 29.1
 +
 -
 Granulocyte development and recruitment
Similar to MAPK phosphatase (cpg21; unpublished)
 BB 442784
 NA
 27.9
 ±
 -
 Potentially, intracellular signal transduction, MAPK inactivation
IL-6
 NM 031168
 [48]
 22.5
 +
 +
 Multiple roles
PROK-2
 NM 015768
 [14]
 21.0
 +
 -
 Macrophage activation, hyperesthesia/pain, angiogenesis, gut motility
P-selectin
 M 72332
 [49]
 20.1
 +
 -
 Leucocyte, platelet adhesion to vascular endothelium
Similar to macrophage inflammatory protein 2 precursor
 BB 829808
 [50]
 20.0
 ±
 -
 Putative neutrophil attracting chemokine
Irg1
 L 38281
 [16]
 19.8
 +
 -
 Induced in macrophages by LPS, mycobacteria
Dual specificity phosphatase 16
 BB 121278
 [51]
 19.4
 ±
 -
 Potentially, intracellular signal transduction, MAPK inactivation
Mus musculus transcribed sequences (unpublished)
 BB 993160
 NA
 18.0
 -
 -
 Unknown

aRole of target gene in inflammation in general. bRole of target gene in MSU crystal inflammation. +, known to play a role; ±, potentially involved; -, not known; CSF, colony-stimulating factor; G-CSF, granulocyte colony stimulating factor; Hdc, histidine decarboxylase; Irg, immunoresponsive gene; LRF, leukaemia/lymphoma-related factor; MAPK, mitogen-activated protein kinase; MSU, monosodium urate; NA, not applicable; PROK, prokineticin; PUMA-g, protein upregulated on macrophages activated with interferon-γ.

Pessler et al. Arthritis Research & Therapy 2008 10:R64   doi:10.1186/ar2435