Table 1

Regression analysis of membrane n-3 LCPUFA content versus lymphocyte subpopulationa numbers and cytokine production

EPA
 DHA
 n-3 LCPUFAc


rb
 p valueb
 r
 p value
 r
 p value
CD3+
 -0.32
 0.07
 -0.06
 0.74
 -0.20
 0.27
CD4+
 -0.34
 0.06
 -0.04
 0.84
 -0.19
 0.28
CD8+
 -0.17
 0.36
 -0.07
 0.70
 -0.12
 0.50
CD4+:CD8+
 0.14
 0.45
 0.01
 0.94
 0.06
 0.73
CD16+CD56+
 -0.39d
 0.025
 -0.37
 0.033
 -0.38
 0.029
CD19+
 -0.13
 0.47
 -0.11
 0.56
 -0.12
 0.50
IFNγ
 0.17
 0.43
 0.13
 0.56
 0.16
 0.50
IL-2
 0.23
 0.30
 0.23
 0.30
 0.26
 0.24
LT
 0.43
 0.046
 0.18
 0.44
 0.27
 0.22
Lymphocytes
 -0.45
 0.009
 -0.21
 0.25
 -0.28
 0.11
Neutrophils
 -0.24
 0.18
 -0.31
 0.065
 -0.31
 0.078
Monocytes
 0.06
 0.80
 0.41
 0.11
 0.28
 0.27
Total leukocytes
 -0.33
 0.06
 -0.32
 0.07
 -0.34
 0.06

aCD3+, all circulating T cells; CD4+, all T helper cells; CD8+, all cytotoxic T cells; CD19+, all B lymphocytes; CD16+CD56+, all NK cells; IFNγ, interferon-gamma; IL-2, interleukin 2; LT, lymphotoxin. bThe correlation coefficient r value; the p value shows the significance (p < 0.05) (ANOVA) of the obtained r value. cn-3 LCPUFA refers to the sum of docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). dBoldfaced text shows results with r value of p < 0.05.

Mukaro et al. Arthritis Research & Therapy 2008 10:R57   doi:10.1186/ar2426