Arthritis Research & Therapy

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Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking

Karen H Costenbader*, Shun-Chiao Chang, Immaculata De Vivo, Robert Plenge and Elizabeth W Karlson

Arthritis Research & Therapy 2008, 10:R52 doi:10.1186/ar2421

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